Chemopreventive action of Phyllanthus urinaria Linn on DMBA-induced skin carcinogenesis in mice.

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dc.contributor.authorBharali, Ren_US
dc.contributor.authorTabassum, Jen_US
dc.contributor.authorAzad, M R Hen_US
dc.date.accessioned2009-05-28T12:31:29Z
dc.date.available2009-05-28T12:31:29Z
dc.date.issued2003-11-31en_US
dc.description.abstractThe inhibition of tumor incidence by hydro-alcoholic extract of the whole plant of P. urinaria was evaluated in 6-7 weeks old female albino mice on two-stage process of skin carcinogenesis induced by a single application of 7,12-dimethylbenz(a)anthracene (50 microg/50 microl of acetone), and 2 weeks later, promoted by repeated application of croton oil (1% in acetone/three times a week) till the end of the experiment (15 weeks). Topical application of the extract at a dose of 5 mg/kg body weight/day for 15 weeks at the peri-initiational stage (i.e., 7 days before and 7 days after DMBA application), promotional stage (i.e., from the time of croton oil application) and both peri and post-initiational stages (i.e., 7 days prior to DMBA application and continued till the end of the experiment) on the shaven backs of the mice recorded a significant reduction in tumor incidence to 50, 33.3 and 16.7% respectively in comparison to the control (i.e., the mice treated with DMBA and croton oil only) where tumor incidence was found to be 81.8%. The average number of papillomas per mouse was also significantly reduced. The results suggest a possible chemopreventive property of P. urinaria against DMBA-induced skin papillomagenesis in mice.en_US
dc.description.affiliationBiochemistry Division, Department of Biotechnology, Gauhati University, Guwahati 781 014, India. rbharali@rediffmail.comen_US
dc.identifier.citationBharali R, Tabassum J, Azad MR. Chemopreventive action of Phyllanthus urinaria Linn on DMBA-induced skin carcinogenesis in mice. Indian Journal of Experimental Biology. 2003 Nov; 41(11): 1325-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58199
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.mesh9,10-Dimethyl-1,2-benzanthracene --toxicityen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCarcinogens --toxicityen_US
dc.subject.meshChemopreventionen_US
dc.subject.meshCroton Oil --administration & dosageen_US
dc.subject.meshFemaleen_US
dc.subject.meshMiceen_US
dc.subject.meshPapilloma --chemically induceden_US
dc.subject.meshPhyllanthus --chemistryen_US
dc.subject.meshPhytotherapyen_US
dc.subject.meshPlant Extracts --isolation & purificationen_US
dc.subject.meshSkin Neoplasms --chemically induceden_US
dc.titleChemopreventive action of Phyllanthus urinaria Linn on DMBA-induced skin carcinogenesis in mice.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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