Dosimetric parameters of heart and left ventricle – comparison of 3D CRT and IMRT in left cancer breast

Simple item page
dc.contributor.authorMehta, Aen_US
dc.contributor.authorKumar, Pen_US
dc.contributor.authorSilambarasan, Nen_US
dc.contributor.authorS., Nen_US
dc.contributor.authorNigam, Jen_US
dc.contributor.authorKumar, Pen_US
dc.contributor.authorChauhan, Aen_US
dc.date.accessioned2020-09-24T07:54:03Z
dc.date.available2020-09-24T07:54:03Z
dc.date.issued2019-12
dc.description.abstractBackground: Conformal Radiotherapy techniques adapting to the ballistics of delineated volumes allowed significant reduction in excess radiation induced mortality however the increasing number of long-term survivors and expanding use of cardiotoxic drug highlight the persistent need for maximal cardiac possible sparing. The low dose volume of left ventricle are better predictor of acute coronary events than mean heart dose. Materials and Methods: 38 post-MRM patients were randomized to treatment by 3Dimensional Conformal Radiotherapy (3D CRT) and Intensity Modulated Radiotherapy (IMRT) technique. Two tangential beams were used in 3D CRT technique while five to seven (mostly tangential beams) were used in inversely planned IMRT technique. The dose volume parameters of planning target volume, heart and left ventricle were compared. Results: The dosimetry of Planning target volume showed significantly better coverage in IMRT technique (D90, D95) however the D50 was comparable in both the techniques. In dosimetry of heart, the high dose volumes (V30, V40) were nearly comparable in both the techniques. The other dose volume parameters (V5, V10, V20, V25, D33, D67, D100) and the mean dose were significantly lesser in 3D CRT technique along with significantly better sparing of left ventricle (Dmean and V5). Conclusion: The dosimetry of target volume was better with IMRT technique, but this was accompanied by a huge increase in dose to whole heart and specifically the left ventricle which has strong potential to translate into an increased cardiotoxicity. A better distribution of the target region may be obtained by multiple segmentation of the two tangential fields in 3D CRT plans with further reduction in dose to heart and left ventricle.en_US
dc.identifier.affiliationsDr. Ankita Mehta Junior Resident, Department of Radiation Oncology, Shri Ram Murti Institute of Medical Sciences, Bareilly, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDr. Piyush Kumar Professor and Head, Department of Radiation Oncology, Shri Ram Murti Institute of Medical Sciences, Bareilly, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDr Mr. N.S. Silambarasan Assistant Professor cum Medical Physicist, Shri Ram Murti Institute of Medical Sciences, Bareilly, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDr Mrs. S. Navitha Assistant Professor cum Medical Physicist, Department of Radiation Oncology, Shri Ram Murti Institute of Medical Sciences, Bareilly, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDr Mr. Jitendra Nigam Assistant Professor cum Medical Physicist, Department of Radiation Oncology, Shri Ram Murti Institute of Medical Sciences, Bareilly, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDr. Pavan Kumar Assistant Professor, Department of Radiation Oncology, Shri Ram Murti Institute of Medical Sciences, Bareilly, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDr. Arvind Chauhan Associate Professor, Shri Ram Murti Institute of Medical Sciences, Bareilly, Uttar Pradesh, Indiaen_US
dc.identifier.citationMehta A, Kumar P, Silambarasan N, S. N, Nigam J, Kumar P, Chauhan A. Dosimetric parameters of heart and left ventricle – comparison of 3D CRT and IMRT in left cancer breast. International Journal of Medical Research & Review. 2019 Dec; 7(6): 468-474en_US
dc.identifier.issn2320-8686
dc.identifier.issn2321-127X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/205306
dc.languageenen_US
dc.publisherSiddharth Health Research and Social Welfare Societyen_US
dc.relation.issuenumber6en_US
dc.relation.volume7en_US
dc.source.urihttps://ijmrr.medresearch.in/index.php/ijmrr/article/view/1096en_US
dc.subject3-Dimensional Conformal Radiotherapy (3D CRT)en_US
dc.subjectIntensity Modulated Radiotherapy (IMRT)en_US
dc.subjectCardiotoxicityen_US
dc.subjectPlanning target volumeen_US
dc.subjectHearten_US
dc.subjectLeft ventricleen_US
dc.titleDosimetric parameters of heart and left ventricle – comparison of 3D CRT and IMRT in left cancer breasten_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijmrr2019v7n6p468.pdf
Size:
589.49 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Medical Research & Review