International Journal of Medical Research & Review

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https://imsear.searo.who.int/handle/123456789/149620

Editor in Chief : Dr. D. Sharad Gedam,

ISSN: 2320–6012(Print)

Frequency: 6 issues a year

Language: English

An Journal of Shishu Mangalam Child Care Centre, Bhopal, India

Open Access Peer-reviewed journal

Web site: https://www.ijmrr.in/ /

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Now showing 1 - 20 of 200

CORRELATION BETWEEN AIRWAY RESISTANCE AS DETERMINED BY R20 AND SEVERITY OF OBSTRUCTIVE SLEEP APNEA AS DETERMINED BY APNEA HYPOPNEA INDEX IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA”
(Siddharth Health Research and Social Welfare Society, 2025-03) Sasidharan, A; Fathahudeen, A
Background: Polysomnography is the gold standard for the diagnosis of patients with obstructive sleep apnea, but its routine use is limited by its cost. R20 measures the resistance of large central airways while R5 corresponds to total airway resistance, in large airway obstruction (as in OSA) central airway resistance (R20) increases and total resistance (R5) increases. This study aims to assess the usefulness of impulse oscillometry in the diagnosis of patients with obstructive sleep apnea, as it is a cost-effective, easy-to-perform investigation. Materials And Methods: The present cross-sectional study included 85 patients suspected to have obstructive sleep apnea. Initial screening was done using the STOP BANG score. Specifically, patients with a score of 0 - 2 are considered at low risk for moderate to severe OSA, while those with a score of 5 -8 are classified as high risk for moderate to severe OSA and in our study those with a score ?3 was advised to perform sleep study with their AHI index noted and subsequently impulse oscillometry noting their R20, R5 and R5-R20. Results: In our study majority of participants (64.3%) fell within the 51-60 age range, which aligns with typical findings indicating a higher prevalence in middle-aged adults. The majority of participants,70 individuals were obese. In our study hypertension was the most prevalent comorbidity associated with OSA Among the 84 study subjects 63.1% of the sample, reported having Type 2 Diabetes Mellitus. 60 participants, making up 71.4% of the sample, reported that they do snore and we demonstrated a good correlation between the severity of OSA and snoring. Conclusion: Impulse oscillometry can be a useful,easy-to-perform test in the evaluation of patients with OSA though further studies are needed.
Six interesting case discussions of adult type 1 diabetes from Karnataka, South India
(Siddharth Health Research and Social Welfare Society, 2025-06) R, Anil Kumar; Karthik, M
Type 1 diabetes can affect adults, although it is more common in children and young adults. We are presenting six cases of adult onset type 1diabetes. The etiology was autoimmune in five persons and idiopathic in one person. Two persons had diabetic ketoacidosis at presentation and four persons had symptoms of hyperglycemia. Fasting c-peptide was measured after blood glucose control and all six persons had very low c-peptide levels. Diabetes may present at any age so when there is strong clinical suspicion of type 1 diabetes in adults, physicians should do fasting C-peptide levels to diagnose type1 diabetes for management.
PROPORTION OF OBSTRUCTIVE AIRWAY DISEASE AMONG POST PULMONARY TUBERCULOSIS SUBJECTS IN A TERTIARY CARE SETTING
(Siddharth Health Research and Social Welfare Society, 2025-03) Akshaya, KT; Fathahudeen, A; Kamala, R
Background: Pulmonary tuberculosis can affect lung function and the pulmonary function test of post-patients shows airway obstruction which is not reversible. This group of patients is in the category of post-TB obstruction syndrome with symptoms and signs similar to Chronic Obstructive Pulmonary Disease (COPD). The objectives of our study are: To determine the factors causing the development of obstructive airway disease in post-tuberculous individuals & To assess the severity of obstruction based on GOLD criteria. Materials and Methods: The study was conducted in the Department of Pulmonary Medicine, Government Medical College Hospital, Thiruvananthapuram. This was a cross-sectional study that included patients with a history of pulmonary tuberculosis, (? 6 months after treatment), the pulmonary function test of each patient was assessed using spirometry as obstruction, restriction, mixed pattern or normal and in obstruction, the severity of obstruction was assessed as mild, moderate, severe, very severe based on GOLD criteria. Results: In our study, 84% of patients had abnormal lung function, with obstruction as the predominant abnormality in 36%, 21.8% demonstrated restrictive abnormalities, and 26.1% showed mixed patterns. Among individuals with obstructive lung disease, the severity of obstruction was assessed based on their post-bronchodilator FEV1% according to GOLD grades for COPD. It was observed that 67.4% had moderate obstruction. The mean FEV1 for the moderate obstruction group, the most prevalent among obstructive cases, was 1.41 litres. Conclusion: Patients with a history of pulmonary tuberculosis in the past, often present with signs of permanent impairment in lung function, which may manifest as obstruction, restriction, or a mixed pattern. Tuberculosis is an independent risk factor for the development of obstructive airway diseases.
Clinical and histopathological profile of patients with exudative pleural effusion of unknown cause who undergo medical thoracoscopy
(Siddharth Health Research and Social Welfare Society, 2025-03) kumar, JVS; Fathahudeen, A
Background: Exudative lymphocytic effusions form a significant proportion of undiagnosed pleural pathologies. This study explores the clinical and histopathological profile of exudative pleural effusion of unknown cause who undergo medical thoracoscopy. Materials And Methods: This cross-sectional study enrolled 37 patients with exudative pleural effusion. Ultrasound-guided thoracentesis was conducted and samples were sent for pleural fluid cytology. Thoracoscopic pleural biopsy was kept as the gold standard. Results: A total of 37 patients were included in the study. 14 (37.83%) were smokers. 19 (51.35%) were exposed to firewood smoke. Only 1 participant (2.7%) reported exposure to passive smoke.5 patients had STEMI/ recent CABG in the last 1 year.1 participant reported a history of Ayurvedic drug intake. There was no asbestos occupational exposure in any of our subjects but 5 of our subjects had mesothelioma. It can be related to an indirect exposure which is absent due to a recall bias. 2 participants reported a history of recent trauma or RTA, but it was unrelated to the final diagnosis. Histopathological profile showed adenocarcinoma in 19(51.35%), tuberculosis in 7(18.9%).Thoracoscopy pleural findings include nodules in 26(70.27%). Conclusion: Our study concluded that pleural nodules on thoracoscopy were suggestive of malignant aetiology with good cytology yield. Pleural metastasis from lung adenocarcinoma has a good yield of cytology and is the most common cause of exudative pleural effusions that underwent medical thoracoscopy.
UNMASKING THE CULPRIT – PSEUDOANEURYSM OF PETROUS INTERNAL CAROTID ARTERY
(Siddharth Health Research and Social Welfare Society, 2025-06) Anju, KR; Swapna, UP; Nikhila, R; Anjali, V
Pseudoaneurysms of the petrous internal carotid artery are rare. This is the case of a patient who presented with intermittent episodes of profuse bleeding from left nostril and pulsatile tinnitus. Digital subtraction angiography (DSA) showed pseudoaneurysm from left petrous internal carotid artery and was promptly treated with balloon assisted coiling.
CORRELATION BETWEEN IMPULSE OSCILLOMETRY AND SPIROMETRY IN ASSESSMENT OF SMALL AIRWAY DYSFUNCTION IN ASYMPTOMATIC SMOKERS
(Siddharth Health Research and Social Welfare Society, 2025-03) Harishankar, S; Sreekala, C; Fathahudeen, A
BACKGROUND: The traditional pulmonary function tests may be inadequate to detect Chronic Obstructive Pulmonary Disease (COPD) pathological damage and smoking-related lung disease. Therefore, more reliable methods for airway evaluation are required for patients with COPD. Impulse oscillation system (IOS) is a novel method for reactance and airway resistance measurements. It is a kind of forced oscillation, where sound waves oscillate at different frequencies, usually between 5 and 20 Hz, and propagate through the bronchial tree. It measures the proximal airway resistance (measured at 20 Hz [R20]), the peripheral airway resistance (measured at R5–R20), and the overall airway resistance (measured at 5 Hz [R5]). Resistance and reactance make up impedance. IOS provides more detailed information than spirometry on regional lung function and should be considered as being complementary to spirometry to comprehensively assess lung function in COPD. Also, small airway dysfunction (SAD), if detected early, can help in preventing progression of the disease with proper counselling and smoking cessation. OBJECTIVES: The objective of our study is to assess the correlation between impulse oscillometry and spirometry parameters in small airway dysfunction in asymptomatic smokers in a tertiary care centre; to determine the association of smoking index with impulse oscillometry small airway dysfunction parameter R5-R20. MATERIALS AND METHODS: Study was conducted in Department of Pulmonary Medicine, Medical college Hospital, Thiruvananthapuram. The present cross- sectional study included asymptomatic current smokers, eligible participants underwent spirometry and oscillometry and results compared. RESULTS: Out of 45 patients studied, 44.4% (n=20), fell within the 45-60 age range. The majority of participants, comprising 37.8% (n=17), had a Smoking Index ranging from 300 to 399. Correlation analysis between FEF (25-75) vs (R5-R20) done by Pearson correlation test reported very mild negative correlation between them (r=-0.053, p=0.728). Chi square test reported significant association between smoking index & R5-R20 (p<0.05). CONCLUSION: Impulse oscillometry is capable to detect SAD in asymptomatic smokers with preserved spirometry and with FEF(25-75) values in the normal range. We verify that IOS offers parameters that can contribute to conventional pulmonary function tests.
Individualized Homoeopathic Medicines Alleviated the Recurrent Epistaxis in Identical Twins with Severe von Willebrand Disease and Haemophilia A: A Duo Case Report.
(Siddharth Health Research and Social Welfare Society, 2025-03) Kumat, O; Kundu, T; Kalda, P; Aswar, C
Background: von Willebrand Disease (vWD) is an inherited genetic bleeding disorder that prevents the blood from clotting. Prevalence of vWD is estimated to be approximately 1% of the population (or 10,000 cases per million population). The vWF binds and stabilizes blood clotting factor (FVIII) in circulation and therefore it helps in clot formation. Case Profiles: This duo case report is the classical example of association of vWD with haemophilia A in identical twins, where both the patients shared the same disease pattern and manifestations like recurrent epistaxis & ecchymotic patches. But when it came to homoeopathic prescription both of them were prescribed 2 different constitutional medicines on the basis of their behavior, constitution, etc. Result & Discussion: ISTH-BAT (International Society on Thrombosis and Haemostasis-Bleeding Assessment Tool) scale was used to measure the frequency of epistaxis and bruises which reduced from 6 to 1 in the elder twin and from 7 to 4 in the younger one. Modified Naranjo Criteria in Homoeopathy was used to assess the homoeopathic result with the score of 10 for the elder twin and 8 for the younger twin. This Duo Case Report signifies the role of two different Individualized Homoeopathic Medicines in the identical twins though sharing the similar disease pattern. Conclusion: Homoeopathic medicines prescribed on the basis of individualization alleviated the genetic disease symptoms and improved the quality of life of the patients’ and the family members.
Understanding Generation Z nursing students and Role of Nursing Faculty and Educators :A Narrative review
(Siddharth Health Research and Social Welfare Society, 2025-03) Sancha, A
The nursing education landscape is undergoing a significant transformation due to generational shifts. A widening gap exists between Generation Y educators and Generation Z and Alpha students, impacting teaching methodologies and curriculum design. Students' readily available access to online information contrasts sharply with educators' past experiences of in-depth research. This necessitates a paradigm shift in teaching approaches to accommodate the unique learning styles and technological proficiency of younger generations. Understanding the sociocultural influences shaping Gen Z students' worldviews, and embracing technology in the classroom, are crucial for effective nursing education and preparing the future nursing workforce. Faculty development focusing on technology integration is essential to bridge the generational divide and ensure successful student learning.
Communication barriers encountered by the undergraduate nursing students and the newly admitted patients while interacting with each other in the tertiary care hospital of Bhopal
(Siddharth Health Research and Social Welfare Society, 2025-06) Anila, E; Aiswarya, S; Aksa, Biju; Anagha, E; Aarsi, Kulshrestha; Anamika, Priya; Verma, M
Introduction: Communication is a lifelong learning process. Clear communication means the information is conveyed effectively between people. As a part of training for nursing service, nursing students have to communicate with patients focusing on the patient's needs and problems. Many nursing students face communication difficulties with their facilitators and patients during their clinical learning. This study aims to determine the communication barriers encountered by the undergraduate nursing students and the newly admitted patients in tertiary care hospital of Bhopal and to find out the association of the communication barriers with the selected socio- demographic variables. Methods: A descriptive, cross sectional study was conducted among 138 undergraduate nursing students and 73 newly admitted patients. The barriers were assessed with the help of a self structured questionnaire and the association was analyzed with frequency, percentage, distribution and fischer’s exact test. Results: Among nursing students, 68.8% reported moderate communication barriers, and 21% faced severe barriers. Among patients, 36% experienced moderate communication barriers and 24.7% of them faced severe communication barriers. This study also concludes that there is significant association between the level of communication barrier with the course and year of study of the undergraduate nursing students and with the highest level of education of the patients. Conclusion: Furthermore, it was also concluded that the most significant barrier among the nursing students and the admitted patients was psychological barrier with those patients who did not neither maintain eye contact nor show interest and with those nursing students who did not maintain a good eye contact nor let them express their ideas, respectively.
Hand grip strength as a marker of functional impairment in chronic obstructive pulmonary disease patients
(Siddharth Health Research and Social Welfare Society, 2025-03) Neena, RS; Fathahudeen, A; Kamala, R
Background: COPD is a heterogeneous lung disease with multisystem involvement. COPD patients not only suffer from respiratory function impairment but also from peripheral muscle dysfunction which is an important manifestation that hinders day-to-day activities. Patients with a reduction in muscle strength should be detected early so that an early intervention through pulmonary rehabilitation can be done. pMDIs which is a common inhalation device in COPD require adequate hand strength for its actuation making the upper limb muscle strength an important parameter which is often ignored in COPD patients. Objectives: To determine the hand grip strength of COPD patients objectively. To determine the association between hand grip strength with FEV1,6-minute walk distance and BODE index. Methods: This is a cross-sectional followed by a prospective observational study conducted in the Department of Respiratory Medicine, Government Medical College, Trivandrum, Kerala. In 72 COPD patients, hand grip strength was assessed using a Camry Digital Dynamometer and was compared with the age and gender-adjusted values. Spirometry was done in all 72 patients and FEV1 measurement was recorded. A 6-minute walk distance was determined; the BODE index was calculated in these patients which comprises BMI, FEV1, Dyspnea on the MMRC scale and distance walked in 6 minutes. Results: COPD patients were found to have a reduction in their hand grip strength compared to their age and gender-adjusted values. In COPD patients, hand grip strength was found to have a positive correlation with a 6-minute walk distance whereas grip strength was found to have a negative correlation with BODE INDEX. Conclusion: Hand grip strength is impaired in COPD patients and it could be used as a marker of functional impairment.
NERVE SHEATH MYXOMA IN AN UNCHARTED TERRITORY
(Siddharth Health Research and Social Welfare Society, 2025-06) Lekshmi, Devi V; Swapna, UP; B, Shyam Kumar; Nikhila, Rajendran; Anjali, Vinod
Dermal nerve sheath myxoma is a rare benign tumor of perineural schwann cells of peripheral nerves1. It commonly affects limbs of younger adults with peak incidence in thirties2 and has a high recurrence rate if not fully excised. This is a case of an elderly female who presented with a swelling in the right nasal cavity. Excision biopsy of the mass was done and histopathology showed features of nerve sheath myxoma.
Role of Yoga Prana Vidya (YPV) system as complementary medicine in the successful treatment of HIV: A case research study
(Siddharth Health Research and Social Welfare Society, 2025-06) Malipeddi, M; Nanduri, VS
Introduction: The human immunodeficiency virus (HIV) is a pathogen that compromises the body's immune system by targeting white blood cells known as CD4 cells. Studies show evidence of successful YPV therapy as complementary in the healing cases of dreaded diseases like cancer, and various other diseases. This paper presents an in-depth case study of a HIV patient treated successfully using YPV protocols as complementary medicine to overcome psychological issues and side effects of ART medication. Method: An in-depth Case study method is used, collecting case details from the Trainer-healer, medical information from patient, and a qualitative research interview of the patient transcribed for thematic analysis. Results; The CD4 figures for the period 2016 to 2022 show fluctuating results (above and below 500 cells /mm-cube) when ART medication was used alone. However, for the period 2022 to 2024 when the patient was treated complementarily using YPV protocols together with ART medication, CD4 values show a stable and rising pattern, above 500 cells/mm-cube. The medical team reduced dosage by 41%. Qualitative analysis shows he is not experiencing any side effects of ART medication, while feeling strong and energetic functioning normally. Conclusions: In addition to medical care, HIV patients require effective psychosocial assistance. A higher quality of life and longer lifespan are possible for individuals living with HIV who have access to timely diagnosis, treatment, and psychosocial support. According to this study, the YPV protocols provide efficient ways for patients to heal and rehabilitate. Recommendations include conducting more studies using right samples and methodology.
Human Metapneumovirus (HMPV) - A Comprehensive Review of Clinical Impact, Epidemiology, and Management Approaches.
(Siddharth Health Research and Social Welfare Society, 2025-03) RUPALI, RV
Human Metapneumovirus (HMPV) is an important viral agent responsible for a range of respiratory diseases, especially among vulnerable populations such as young children, the elderly, and those with weakened immune systems. This review highlights the clinical features, epidemiology, diagnostic challenges, and therapeutic strategies related to HMPV infections. The absence of specific antiviral treatments and vaccines for HMPV represents a significant challenge in clinical practice. Understanding its pathogenesis, refining diagnostic methods, and advancing research into vaccines and therapeutics are essential to better manage and prevent this infection.
Challenges and Opportunities in Normothermic Liver Perfusion: A Standard Research Review from an Indian Perspective
(Siddharth Health Research and Social Welfare Society, 2025-06) Kothwala, D; Durani, O; Jithendran, A; Gautam, K
Liver transplantation is the only definitive treatment for end-stage liver disease and acute liver failure; however, the shortage of viable donor organs remains a critical challenge. Conventional static cold storage (SCS), while widely used, is associated with ischemia-reperfusion injury, leading to suboptimal graft function. Normothermic liver perfusion (NLP) has emerged as an advanced preservation technique that mimics physiological conditions, thereby reducing cellular injury, extending preservation times, and improving organ viability. Studies have demonstrated that NLP enhances graft recovery, facilitates viability assessment, and increases the utilization of marginal donor livers. Despite these advantages, the implementation of NLP in India is hindered by high costs, infrastructure limitations, and the need for specialized expertise. However, with increased investment in healthcare, research collaborations, and regulatory support, NLP could revolutionize liver transplantation in India by improving transplant outcomes and expanding the donor pool. This review explores the clinical benefits, challenges, and potential pathways for integrating NLP into India’s organ transplantation framework, highlighting the need for strategic policy interventions, cost-effective solutions, and workforce training to enable widespread adoption.
CASE REPORT CREST Syndrome: A Rare Cause of Chronic Upper-Gastro Intestinal Haemorrhage in Adults
(Siddharth Health Research and Social Welfare Society, 2025-06) Sj, Sanketh; Charantimath, NC; Ugaragol, P
Background: CREST syndrome, a limited cutaneous variant of systemic sclerosis, rarely presents with chronic upper gastrointestinal haemorrhage. This case report explores the complex pathological mechanisms and management challenges of this uncommon manifestation. Case Presentation: A 52-year-old female with established CREST syndrome presented with recurrent melena and hematemesis. Comprehensive clinical evaluation revealed extensive gastrointestinal telangiectasia with significant bleeding potential. Upper endoscopy demonstrated multiple fragile vascular lesions throughout the esophagus, stomach, and duodenum.The patient underwent detailed diagnostic imaging, including CT angiography and capsule endoscopy. Therapeutic interventions included argon plasma coagulation, tranexamic acid therapy, and systemic immunosuppression with mycophenolatemofetil.
Laparoscopic Versus Open Surgical Outcomes Repair For Inguinal Hernia- A Combined Prospective And Retrospective Cohort Study
(Siddharth Health Research and Social Welfare Society, 2024-10) Islam, MS; Faizi, SAM; Rahman, MZ; Alam, RJ; Hossain, MJ; Miraj, AKA.
Inguinal hernias are common and have become a common surgical problem. In recent decades, the nature of their treatment has changed and new research is constantly being conducted in this field. To find out the assessment the laparoscopic versus open surgical outcomes repair for inguinal hernia. A combined Prospective and retrospective Cohort study was carried out February 2023 to March 2024 in Department of General Surgery BSMMU. The sample size was two hundred for each arm; patients aged 18 and above without factors pre-disposing to recurrence were included in the study. The subjects were followed up for a period of one year at the end of which primary outcome assessed was recurrence. A number of secondary outcomes such as hematoma, persistent pain and return to regular activity were also assessed. Among the 100 individuals analyzed, 75 (75%) were male patients, with the majority of them falling between the ages of 41 and 55. In contrast to the open group of patients, the laparoscopic group experienced a significant increase in operative time with a highly significant statistical difference (p<0.0001), and the laparoscopic group experienced a significant decrease in post-operative pain score with an insignificant p-value. A significant statistical difference (p<0.005) was estimated among the laparoscopic and open groups of patients in terms of post-operative hospitalization. Returning to normal activities was significantly different for laparoscopic patients relative to the open group (p-value<0.001). With a high level of significance of p<0.001, laparoscopic hernia repair required less time to recover before returning to normal activities than open hernia repair (p<0.005). However, we observed that 90% of the recurrences in the laparoscopic arm were at the hands of surgeons with less than five years’ experience in laparoscopic surgery which was statistically highly significant (P value = 0.00). In the open arm however, the surgeons’ experience did not alter the outcome significantly (P value = 0.341). Thus, laparoscopic repair for inguinal hernia is a safe alternative in the hands of experienced laparoscopic surgeons.
A Study Of The Diaphyseal Nutrient Foramina Of Dried Bangladeshi Fibulae
(Siddharth Health Research and Social Welfare Society, 2024-10) Fatima, K; Khan, M; Tahmina, M; Islam, NB; Jahan, I; Leeza, NI.
Context: The fibula serves crucial functions in lower limb biomechanics and is frequently used in reconstructive surgery. Understanding its nutrient foraminal patterns is essential for surgical success and forensic applications. However, population-specific data for Bangladeshi fibulae has been lacking. Objectives: To determine the morphometric characteristics of diaphyseal nutrient foramina in dried Bangladeshi fibulae. Methods: This cross-sectional analytical study examined 120 dry fully ossified left human fibulae (68 male, 52 female) at Dhaka Medical College. Measurements included total length, diaphyseal dimensions, nutrient foraminal characteristics (number, position, direction), and talar facet parameters. Sexual dimorphism was assessed using unpaired Student's t-test and chi-square test. Results: Significant sexual dimorphism was observed in total length (male: 35.41 ± 1.67 cm, female: 32.72 ± 1.28 cm, p<0.001), midshaft diameter (male: 14.01 ± 1.07 mm, female: 13.21 ± 0.85 mm, p<0.001), and nutrient foraminal measurements. Single nutrient foramen predominated in both sexes (male: 95.6%, female: 92.3%), with primarily downward direction (male: 95.6%, female: 100%). Type-2 Foraminal Index was most common (male: 98.5%, female: 98.1%). Nutrient foramina were predominantly located on the posterior surface in males (42.6%) and medial crest in females (32.7%). Conclusion: This study establishes baseline morphometric data for Bangladeshi fibulae, demonstrating significant sexual dimorphism and consistent nutrient foraminal patterns. These findings have immediate applications in surgical planning, particularly for fibular grafting procedures, and provide valuable reference data for forensic sex determination in the Bangladeshi population.
A Case Series Report on Congenital pulmonary airway malformation – antenatal diagnosis and post-natal follow up
(Siddharth Health Research and Social Welfare Society, 2024-08) Sahu, S; Khokan, M; Guha Roy, A.
Congenital pulmonary airway malformation is the most commonly detected congenital lung defect in the ante-natal period. CPAM is a rare developmental, non-hereditary dysplastic lung lesion. No obvious association with maternal age, race or exposure to any given factor could be ascertained. It has an incidence about 1:1500-4000 of all live birth. We present four cases of congenital pulmonary airway malformation: antenatally detected by ultrasound with their follow up in post-natal period. Three of them have normal uneventful post-natal period. One child was normal for six months of age then developed frequent respiratory tract infection.
Comparison of deferasirox and deferoxamine effects on iron overload in patients with blood transfusion-dependent ?-thalassemia
(Siddharth Health Research and Social Welfare Society, 2024-10) Wohab, MA; Hossain, MB; Choudhury, NAB; Ara, UN.
Introduction: Beta-thalassemias is autosomal recessive hematological disorder prevalent in the Mediterranean area due to defects in synthesis of ? chains of hemoglobin. The aim of present study was to compare the effects of deferasirox and deferoxamine on iron overload in patients with blood transfusion-dependent ?-thalassemia major and intermedia. Patients And Methods: This study involved 100 patients with known cases of ?-thalassemia major or intermedia that has been treated with blood transfusion and iron chelators from January 2020 to December 2023. Serum ferritin, serum iron, serum total iron binding capacity were assessed in deferoxamine and deferasirox-treated patients. Results: In deferoxamine-treated patients, serum ferritin levels were high (4600.56 + 119.2ng/dL) compared to deferasirox-treated patients (3000.261 ± 121.2 ng/dL; P< 0.0001), also there were significant differences in serum iron and total iron-binding capacity (P< 0.0001) in deferasirox-treated patients compared to deferoxamine-treated patients. Conclusion: This study indicated that deferasirox is more effective than deferoxamine regarding the iron overload in patients with blood transfusion-dependent ?-thalassemia.
A SUSPECTED CASE OF ACUTE APPENDICITIS REVELAED TO BE ISOLATED SUBMUCOSAL LIPOMATOSIS OF APPENDIX ON COMPUTED TOMOGRAPHY: A CASE REPORT
(Siddharth Health Research and Social Welfare Society, 2024-08) Biswas, P; Supriya, M.
Symptomatic isolated submucosal intestinal lipomatosis is rare. Also, few cases have been reported in the literature. Here, we are presenting computed tomogr aphy findings of a rare case of isolated submucosal lipomatosis of the appendix presumptiv ely diagnosed as acute appendicitis in a 72-year- old female. This case highlights the importance of considering isolated submucosal lipomatosis as a differential diagnosis in instances of suspected acute appendicitis, especially when clinical findings are inconclusiv e.

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