Effects of pentazocine on dopamine-dependent behaviours in mice.

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dc.contributor.authorBhosale, B Ben_US
dc.contributor.authorBalsara, J Jen_US
dc.contributor.authorJadhav, J Hen_US
dc.date.accessioned2009-05-28T14:03:23Z
dc.date.available2009-05-28T14:03:23Z
dc.date.issued1997-05-01en_US
dc.description.abstractPentazocine, a kappa opioid receptor agonist, induced catalepsy in mice suggesting thereby that it might possess postsynaptic striatal D 2 dopamine (DA) receptor blocking activity. However, our other findings, that pentazocine pretreatment did not antagonise the cage climbing behaviour induced by the directly acting DA agonist apomorphine in mice and actually potentiated the stereotyped behaviour induced by the indirectly acting DA agonist methamphetamine in mice, indicate that pentazocine does not possess postsynaptic striatal and mesolimbic D 2 DA receptor blocking activity. Pretreatment with naloxone, an antagonist of opioid receptors, antagonised pentazocine-induced catalepsy. This suggests the possible involvement of opioid mechanisms in the induction of catalepsy by pentazocine in mice.en_US
dc.description.affiliationDepartment of Pharmacology, Krishna Institute of Medical Sciences, Karad, India.en_US
dc.identifier.citationBhosale BB, Balsara JJ, Jadhav JH. Effects of pentazocine on dopamine-dependent behaviours in mice. Indian Journal of Experimental Biology. 1997 May; 35(5): 448-50en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/60213
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDopamine Antagonists --pharmacologyen_US
dc.subject.meshLocomotion --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshPentazocine --pharmacologyen_US
dc.subject.meshReceptors, Opioid, kappa --agonistsen_US
dc.subject.meshStereotyped Behavior --drug effectsen_US
dc.titleEffects of pentazocine on dopamine-dependent behaviours in mice.en_US
dc.typeJournal Articleen_US
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