Significance of monosynaptic and polysynaptic reflexes in neonatal rat spinal cord in vitro.

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dc.contributor.authorDeshpande, S Ben_US
dc.date.accessioned2009-05-28T11:36:19Z
dc.date.available2009-05-28T11:36:19Z
dc.date.issued1993-10-01en_US
dc.description.abstractStimulation of a dorsal root in an isolated spinal cord, elicited a monosynaptic reflex (MSR) in the corresponding ventral root at a latency of 3-5 msec and a dorsal root reflex (DRR) in an adjacent dorsal root 2-3 times the latency of MSR. The magnitude of DRR was 10 times smaller than the MSR. These reflexes could be decreased by the agents which suppress synaptic transmission e.g. either by decreasing the [Ca2+]0 or by increasing [Mg2+]0. In the absence of magnesium ([Mg2+]0) in the perfusing medium, the MSR was 15-20% greater in its magnitude and the segmental polysynaptic reflex (PSR) was distinctly seen at 8-10 msec latency. Segmental PSR disappeared when [Mg2+]0 ions are added to perfusing medium probably indicating the involvement of N-methyl-D-aspartate receptors. Further, in this preparation homosynaptic inhibition and pre- or post-synaptic inhibitions could be elicited. This preparation, thus serves as useful model for the study of central synaptic transmission to study the pharmacological or neurotoxic agents.en_US
dc.description.affiliationDepartment of Physiology, Banaras Hindu University, Varanasi, India.en_US
dc.identifier.citationDeshpande SB. Significance of monosynaptic and polysynaptic reflexes in neonatal rat spinal cord in vitro. Indian Journal of Experimental Biology. 1993 Oct; 31(10): 850-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/56947
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshMagnesium --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshReflex, Monosynaptic --drug effectsen_US
dc.subject.meshSpinal Cord --physiologyen_US
dc.subject.meshTemperatureen_US
dc.titleSignificance of monosynaptic and polysynaptic reflexes in neonatal rat spinal cord in vitro.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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