Suitability of limited sampling strategy to cyclosporine A oral formulation.

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dc.contributor.authorSingh, Sen_US
dc.contributor.authorSharma, D Ren_US
dc.contributor.authorSingh, Aen_US
dc.date.accessioned2009-05-28T16:14:12Z
dc.date.available2009-05-28T16:14:12Z
dc.date.issued2000-08-01en_US
dc.description.abstractTherapeutic drug monitoring of cyclosporine A in renal transplant patients is normally performed by measuring pre-dose trough levels or doing area under the curve profiles from all possible sampling points. On the basis of good correlation between predicted area under the curve from limited sampling points and actual area under the curve (literature survey), a limited sampling strategy at 1, 3 and 5 hr was used and extended this strategy as a criteria for pilot evaluation of modified cyclosporine A formulations. Hemodialysis patients served as subjects for the study. Panimun Bioral was used as a test formulation while Sandimmun Neoral as standard reference. The study revealed that both formulations had similar restricted AUC0-5h profiles.en_US
dc.description.affiliationDepartment of Medical Research, Panacea Biotec Ltd., B-1 Ext./A-27, Mohan Co-op Industrial Estate, Mathura Road, New Delhi 110 044, Indiaen_US
dc.identifier.citationSingh S, Sharma DR, Singh A. Suitability of limited sampling strategy to cyclosporine A oral formulation. Indian Journal of Experimental Biology. 2000 Aug; 38(8): 824-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/62979
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshArea Under Curveen_US
dc.subject.meshCyclosporine --administration & dosageen_US
dc.subject.meshDrug Monitoringen_US
dc.subject.meshHumansen_US
dc.subject.meshRenal Dialysisen_US
dc.titleSuitability of limited sampling strategy to cyclosporine A oral formulation.en_US
dc.typeJournal Articleen_US
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