Detection of 3243 A/G and 3316 G/A mitochondrial DNA mutations in Nagpur population

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dc.contributor.authorDongre, Utpal Jagdishen_US
dc.contributor.authorMeshram, Virendra Govindraoen_US
dc.date.accessioned2020-10-16T08:50:35Z
dc.date.available2020-10-16T08:50:35Z
dc.date.issued2020-05
dc.description.abstractThe present study aims to detect 3243 A/G and 3316 G/A mitochondrial DNA (mtDNA) mutations in Nagpurpopulation. Total of 142 patients of type 2 diabetes mellitus and 142 healthy control individuals were selected forthe study from Nagpur city. Selected mutations studied using restriction fragment length polymorphism methodand confirmed by DNA sequencing. Results showed that 3316 G/A mt DNA mutation found in seven patientsof type 2 diabetes mellitus with a 4.92% prevalence, however, found absent in healthy control individuals. ChiSquare and Fisher's exact test showed a significant association between healthy control individuals and type 2diabetes mellitus patients detected with 3316 G/A mutation (p ≤ 0.01). ODDS ratio found significant (for 95%CI; p = 0.05) for 3316 G/A mutation. Furthermore, we did not find 3243 A/G mtDNA mutation in the studiedpopulation. Among studied mutations, 3316 G/A mutation in the ND1 gene is a pathogenic mutation that mayresponsible for type 2 diabetes mellitus in the Nagpur population.en_US
dc.identifier.affiliationsDepartment of Biochemistry, Dr. Ambedkar College, Nagpur, India.en_US
dc.identifier.affiliationsDepartment of Biochemistry, RTM Nagpur University, Nagpur, India.en_US
dc.identifier.citationDongre Utpal Jagdish, Meshram Virendra Govindrao. Detection of 3243 A/G and 3316 G/A mitochondrial DNA mutations in Nagpur population. Journal of Applied Biology & Biotechnology. 2020 May; 2020 May: 37-41en_US
dc.identifier.issn2455-7005
dc.identifier.issn2347-212X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/209903
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber3en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org//10.7324/JABB.2020.80307en_US
dc.subjectMitochondrial DNAen_US
dc.subject3316 G/A mutationen_US
dc.subject3243 A/Gmutationen_US
dc.subjectDNA sequencingen_US
dc.subjectheteroplasmyen_US
dc.subjecthomoplasmy.en_US
dc.titleDetection of 3243 A/G and 3316 G/A mitochondrial DNA mutations in Nagpur populationen_US
dc.typeJournal Articleen_US
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