Study of anticonvulsant activity of acetazolamide on albino rats and its influence on anticonvulsant activity of sodium valproate

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dc.contributor.authorK. H., Hemanth Kumaren_US
dc.contributor.authorM. S., Kishoreen_US
dc.date.accessioned2020-04-23T07:49:34Z
dc.date.available2020-04-23T07:49:34Z
dc.date.issued2018-05
dc.description.abstractBackground: Epilepsy is a common neurological disorder. 30-40% of patients will continue to have seizures despite the use of antiepileptic drugs either alone or in combination. The present study is undertaken to evaluate the anticonvulsant activity of Acetazolamide (ACZ) in albino rats and its influence on anticonvulsant activity of sodium valproate.Methods: Albino rats (150-200gms) of male sex were randomly selected, from central animal facility, MMCRI, Mysore. They were divided into 6groups (per model) of 6 rats each, control group-normal saline 0.5ml, standard group-sodium valproate (300mg/kg), dose 1-ACZ (8.75mg/kg), dose 2-ACZ (17.5mg/kg) and dose 3-ACZ (35mg/kg), dose 4-ACZ (8.75mg/kg) with sodium valproate (150mg/kg). The anti-convulsant activity was screened using MES model and PTZ model.Results: Results were analysed by ANOVA followed by post hoc Fisher’s LSD test. The ACZ has shown anticonvulsant activity at the dose of 17.5mg/kg and 35mg/kg body weight and combination of ACZ 8.75mg/kg with sodium valproate 150mg/kg both in MES model and PTZ model. The anticonvulsant activity of ACZ was less when compared to Sodium Valproate in both MES model and PTZ model. The anticonvulsant activity of combination, ACZ 8.75mg/kg with Sodium valproate 150mg/kg was comparable and more significant when compared to standard drug alone in MES model and PTZ model.Conclusions: The ACZ has shown anticonvulsant activity in MES model and PTZ induced seizure model of epilepsy. This study has shown that ACZ potentiated the effect of sodium valproate and can be used as add on drug with sodium valproate in epilepsy.en_US
dc.identifier.affiliationsDepartment of Pharmacology Mysore Medical College and Research Institute, Irwin Road, Mysuru, Karnataka 570001, Indiaen_US
dc.identifier.citationK. H. Hemanth Kumar, M. S. Kishore. Study of anticonvulsant activity of acetazolamide on albino rats and its influence on anticonvulsant activity of sodium valproate. International Journal of Basic & Clinical Pharmacology. 2018 May; 7(5): 976-985en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199690
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber5en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20181646en_US
dc.subjectAcetazolamideen_US
dc.subjectEpilepsyen_US
dc.subjectMaximal electroshock seizure modelen_US
dc.subjectNephrotoxicityen_US
dc.subjectPentylene tetrazoleen_US
dc.subjectTonic hind limb extensionen_US
dc.titleStudy of anticonvulsant activity of acetazolamide on albino rats and its influence on anticonvulsant activity of sodium valproateen_US
dc.typeJournal Articleen_US
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