Sarcoma in Iran.

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dc.contributor.authorSadighi, Sen_US
dc.contributor.authorRaafat, Jen_US
dc.date.accessioned2009-05-27T17:52:00Z
dc.date.available2009-05-27T17:52:00Z
dc.date.issued2003-04-24en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractPURPOSE: To review the clinical characteristics of 1470 sarcoma cases and to define the factors in patients that predict out come, relapse and survival. METHODS: Retrospective analysis of the database for the period 1991-2002, focusing on demographic, tumor related and treatment related variables, relapse free survival (RFS) and overall survival (OS) using the Kaplan- Meier method. Statistical significance was evaluated using the chi square and t- tests for univariate influence and a Cox regression model for multivariate influence. RESULTS: Mean age was 30 years. The male to female ratio was 3/2 and 23% of the cases were under 16 years of age. Median tumor diameter was 10.5 centimeters. The bone to soft tissue sarcoma ratio was 3/1 in children and 1/3 in adults. Osteosarcoma, Ewing's tumours and rhabdomyosarcomas accounted for 83% of childhood tumors. In adults osteosarcomas, synovial sarcomas and malignant fibrous histocytomas (MFHs) were the most common subtypes. Mean follow up time was 56 months. Of the total, 25% had initial metastasis, 86% received chemotherapy and 41 % underwent radiotherapy. The main prognostic factors for survival were tumor size, margin of surgery, neurovascular involvement in the pathological report, initial metastasis and no complete response to first therapy. Adjuvant radiotherapy, small tumor size, curative surgery with chemotherapy and free surgical margins were significantly associated with reduced recurrence. CONCLUSION: Our patients are characterised by diagnosis with a large tumor size, advanced stage of disease and short survival. A complete response to primary therapy is the main independent variable for overall survival. Earlier diagnosis and an experienced team including surgical, medical and radiotherapy oncologists are needed for a better response and longer survival of patients.en_US
dc.description.affiliationCancer Research Institute, Tehran University of Medical Sciences, Oncology Department, Central Hospital, Keshavarz BLVD, Tehran, Iran. ssadighi@doctor.comen_US
dc.identifier.citationSadighi S, Raafat J. Sarcoma in Iran. Asian Pacific Journal of Cancer Prevention. 2003 Apr-Jun; 4(2): 95-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/38051
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIran --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSarcoma --epidemiologyen_US
dc.subject.meshSurvival Rateen_US
dc.titleSarcoma in Iran.en_US
dc.typeJournal Articleen_US
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