Effects of Salacia oblonga on aluminium induced changes in membrane ATPases in brain cortex and hematological parameters in Wistar albino rats

Simple item page
dc.contributor.authorC. M., Divyashanthien_US
dc.contributor.authorA., Nandhinien_US
dc.contributor.authorDatchanamurty, Barathaneen_US
dc.date.accessioned2020-04-23T07:56:22Z
dc.date.available2020-04-23T07:56:22Z
dc.date.issued2019-06
dc.description.abstractBackground: The current study was done to evaluate the effect of hydro alcoholic extract of Salacia oblonga on aluminum induced toxicity in brain cortex and blood in Wistar albino rats.Methods: The experimental animals were divided into four groups, each group comprising of six animals for 36 days of experimental duration. We investigated Na+/K+, Mg2+, Ca2+ ATPases enzyme activity in brain cortex and hematological changes if any, upon administration of aluminum chloride (Alcl3) (300 mg/kg b.w), hydro alcoholic extract of Salacia oblonga (67 mg/kg b.w) and Alcl3+ Salacia oblanga with control (distilled water).Results: In brain cortex, Salacia caused an increased in activity of ATPases. Combined administration of Salacia suppressed the influence of aluminum on the ATPases in the brain cortex (p<0.05). Both aluminum as well as Salacia did not cause any alteration in the hemoglobin content of blood in Wistar albino rats. The erythrocytes count was also not altered by treatment with either aluminum or Salacia. Combined treatment with Salacia suppressed the influence of aluminum with reference to neutrophil count and significant increases in monocyte as well as lymphocyte count were seen. Thus, repeated administration of aluminum causes a decrease in neutrophil and increase in lymphocyte count.Conclusions: All the ATPases in brain cortex were found to be affected by aluminum administration and Salacia is found to counteract the ATPase effect to a particular extent implying the presence of an active principle that can counteract the aluminium toxicity indicating its possible usefulness in aluminum toxicity.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Vinayaka Missions Medical College, Vinayaka Missions Research Foundation (DU), Karaikal, Puducherry, Indiaen_US
dc.identifier.affiliationsLecturer, Asan memorial dental college and hospital, Chengalpattu, Kanchipuram district, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Puducherry, Indiaen_US
dc.identifier.citationC. M. Divyashanthi, A. Nandhini, Datchanamurty Barathane. Effects of Salacia oblonga on aluminium induced changes in membrane ATPases in brain cortex and hematological parameters in Wistar albino rats. International Journal of Basic & Clinical Pharmacology. 2019 Jun; 8(6): 1215-1220en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200180
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber6en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20192115en_US
dc.subjectAluminiumen_US
dc.subjectMembrane ATPaseen_US
dc.subjectSalacia oblonga extract Toxicityen_US
dc.titleEffects of Salacia oblonga on aluminium induced changes in membrane ATPases in brain cortex and hematological parameters in Wistar albino ratsen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijbcp2019v8n6p1215.pdf
Size:
254.27 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Basic & Clinical Pharmacology