Adverse drug reactions and treatment outcome analysis in multidrug resistant tuberculosis patients at a DOTS plus site

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dc.contributor.authorVelingker, Anitaen_US
dc.contributor.authorLawande, Durgaen_US
dc.date.accessioned2020-04-23T08:01:43Z
dc.date.available2020-04-23T08:01:43Z
dc.date.issued2020-04
dc.description.abstractBackground: Multidrug resistant tuberculosis (MDR TB) requires treatment with expensive, toxic, anti-tubercular drugs over a longer duration. Adverse drug reaction (ADR) to second line anti tubercular drugs affect compliance and hence treatment outcome. The primary objective of this study was to analyse ADRs and if these resulted in change or permanent suspension of drug. We also analysed treatment outcome, treatment adherence and co morbidities associated with MDR patients.Methods: A retrospective study was carried out at DOTS plus site in department of Pulmonary Medicine, Goa Medical College on registered MDR cases from November 2011 to October 2016. Socio demographic profile, diagnosis, treatment and ADRs were evaluated, ADRs were evaluated for frequency, causative drugs, management aspect and impact on treatment outcome.Results: Out of 201 MDR cases, 99 cases had 167 ADRs. Majority of patients having ADRs were in age group of 30-50 years with mean眘tandard deviation 36.82�.47, 59 (59.59%) males and 40 (40.40%) females, 92 (92.92%) retreatment cases and 7 (7.07%) newly diagnosed. Majority of ADRs were vomiting 31(18.56%), joint pain 31 (18.56%), gastritis 21 (12.57%), hearing impairment 16 (9.58%), numbness in leg 14 (8.38%), depression 12 (7.18%). Treatment outcome of cases with ADR was cured 45 (45.45%), treatment completed16 (16.16%), progressed to XDR 6 (6.06%), transferred out 5 (5.05%), defaulter 14 (14.14%), death 13 (13.13%).Conclusions: It is very important to recognise at the earliest and treat the ADRs with least modification of the treatment regimen to have a good treatment outcome.en_US
dc.identifier.affiliationsDepartment of Pulmonary Medicine, Goa Medical College, Panaji, Goa, Indiaen_US
dc.identifier.citationVelingker Anita, Lawande Durga. Adverse drug reactions and treatment outcome analysis in multidrug resistant tuberculosis patients at a DOTS plus site. International Journal of Basic & Clinical Pharmacology. 2020 Apr; 9(4): 547-551en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200597
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20201174en_US
dc.subjectAdverse drug reactionen_US
dc.subjectADR managementen_US
dc.subjectDOTS plusen_US
dc.subjectMDR TBen_US
dc.subjectRNTCPen_US
dc.titleAdverse drug reactions and treatment outcome analysis in multidrug resistant tuberculosis patients at a DOTS plus siteen_US
dc.typeJournal Articleen_US
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