Male reproductive toxic effects of carbendazim: hitherto unreported targets in testis.

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dc.contributor.authorKadalmani, Ben_US
dc.contributor.authorGirija, Ren_US
dc.contributor.authorFaridha, Aen_US
dc.contributor.authorAkbarsha, M Aen_US
dc.date.accessioned2009-05-28T15:04:22Z
dc.date.available2009-05-28T15:04:22Z
dc.date.issued2002-01-04en_US
dc.description.abstractCarbendazim (MBC), a widely used fungicide, is toxic to male reproductive mechanisms. Various cellular targets in the testis for MBC action are being understood only recently and still more targets have been conceived. The present study was aimed at finding such newer targets. Male rats were administered through oral route a single dose of carbendazim (400 mg/kg) and the testis was studied adopting routine histological technique. It has been observed that pachytene spermatocytes could also be targets for MBC action in the testis. The study also reports selective loss of step 14 spermatids, asynchrony of the stages in the spermatogenic cycle and development of Sertoli cell fibrosis of the seminiferous tubules of carbendazim-treated rats. From the different kinds of responses seen in the seminiferous tubules in the same testis to MBC, particularly in the Sertoli cell, MBC action in the testis appears dependent on the stage in the spermatogenic cycle at first exposure.en_US
dc.description.affiliationDepartment of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli 620 024, India.en_US
dc.identifier.citationKadalmani B, Girija R, Faridha A, Akbarsha MA. Male reproductive toxic effects of carbendazim: hitherto unreported targets in testis. Indian Journal of Experimental Biology. 2002 Jan; 40(1): 40-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61520
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAir Pollutants, Occupational --toxicityen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBenzimidazoles --administration & dosageen_US
dc.subject.meshCarbamatesen_US
dc.subject.meshHistocytochemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSertoli Cells --drug effectsen_US
dc.subject.meshSpermatids --drug effectsen_US
dc.subject.meshSpermatocytes --drug effectsen_US
dc.subject.meshSpermatogenesis --drug effectsen_US
dc.subject.meshTestis --drug effectsen_US
dc.titleMale reproductive toxic effects of carbendazim: hitherto unreported targets in testis.en_US
dc.typeJournal Articleen_US
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