Nephrotoxicological Effect of Water Soluble Fraction of Bonny Light Crude Oil in Wistar Albino Rats

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dc.contributor.authorAbrahamen_US
dc.contributor.authorChiedozie, Nicholasen_US
dc.contributor.authorJ., Udomen_US
dc.contributor.authorGodwinen_US
dc.contributor.authorC., Patrick-Iwuanyanwuen_US
dc.contributor.authorKingsleyen_US
dc.date.accessioned2020-05-05T07:04:29Z
dc.date.available2020-05-05T07:04:29Z
dc.date.issued2019-12
dc.description.abstractThis study evaluated the Nephrotoxic effect of water soluble fraction (WSF) of Bonny Light Crude Oil (BLCO). After preparation of the WSFand a range finding test, the Wistaralbino rats were administered three concentrations (25%, 50% and 100%) of WSF of BLCO for 30 and 60days. Data from the study showed that Urea concentration increased significantly (p≤0.05) with increasing dose of BLCO ranging from 14.71mg/dl in the control to 35.28mg/dl in the 100% group after 30days and 14.28mg/dl in the control to 41.08mg/dl in the 100% group after 60days, Creatinine concentration increased significantly (p≤0.05) from 0.22mg/dl in the control to 0.82mg/dl in the 100% group after 60 days administration while electrolyte (Na, K, Cl) concentration increased significantly (p≤0.05) with increasing dose of BLCO after 60days administration. Histopathological examination of the kidney was characterized by partial partitioning of the glomerular tufts, obliteration of the Bowman’s capsule and distortion of the renal tubules. The findings in this research suggest that WSF of BLCO induced nephrotoxicity.en_US
dc.identifier.affiliationsInstitute of Natural Resources Environment and Sustainable Development, University of Port Harcourt, Nigeria.en_US
dc.identifier.affiliationsCentre for Petroleum Geoscience, University of Port Harcourt, Nigeria.en_US
dc.identifier.affiliationsWorld Bank Africa Centre of Excellence for Public Health and Toxicological Research, University of Port Harcourt, Nigeriaen_US
dc.identifier.citationAbraham, Chiedozie Nicholas, J. Udom, Godwin, C. Patrick-Iwuanyanwu, Kingsley. Nephrotoxicological Effect of Water Soluble Fraction of Bonny Light Crude Oil in Wistar Albino Rats . International Journal of Biochemistry Research & Review. 2019 Dec; 28(4): 1-9en_US
dc.identifier.issn2231-086X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200759
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber4en_US
dc.relation.volume28en_US
dc.source.urihttps://doi.org/10.9734/IJBCRR/2019/v28i430151en_US
dc.subjectWater soluble fractionen_US
dc.subjectbonny light crude oilen_US
dc.subjectureaen_US
dc.subjectcreatinineen_US
dc.subjectnephrotoxicityen_US
dc.titleNephrotoxicological Effect of Water Soluble Fraction of Bonny Light Crude Oil in Wistar Albino Ratsen_US
dc.typeJournal Articleen_US
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