Anti-hyperglycemic Effect of Khaya senegalensis Stem Bark Aqueous Extract in Wistar Rats.
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Date
2012-01
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Abstract
Aim: To investigate anti-hyperglycemic effect of aqueous extract of Khaya senegalensis
stem bark (KSE) in alloxan-diabetic Wistar rats.
Methodology: Thirty rats were randomly divided into six groups of 5 animals each.
Group I (non-diabetic control) was given distilled water orally. Animals in the remaining
five groups were treated with a single dose of alloxan (120mg/kg body weight, i.p) to
induce diabetes mellitus. This resulted in significant increase in the fasting blood glucose
level of the rats. Group I (non-diabetic control) and group II (hyperglycemic control) then
received distilled water orally for 14 days. Group III, IV and V were treated orally with
daily doses of 50, 100 and 150 mg/kg body weight of KSE respectively for 14 days.
Group VI was given glibenclamide (5mg/kg, p.o) for the same period. Fasting blood
glucose was determined by oxidative method in all the groups on day 0 (before
treatment), day 7 and day 14. Oral glucose tolerance test and erythrocyte
malondialdehyde (MDA) concentration were estimated after the two week treatment.
Body weights of the animals were also measured on day 0, day 7 and day 14.
Results: Treatment with KSE and glibenclamide caused significant (p<0.05) and dosedependent
changes compared to the untreated animals with respect to body weight,
blood glucose level and erythrocyte malondialdehyde (MDA) concentration. The antihyperglycemic
effect of KSE was comparable to that of the standard drug, glibenclamide.
Conclusion: The study showed that aqueous extract of Khaya senegalensis stem bark
possesses anti-hyperglycemic activity.
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Keywords
Diabetes, lipoperoxidation, erythrocyte, alloxan, glibenclamide
Citation
Kolawole O T, Kolawole S O, Ayankunle A A, Olaniran O I. Anti-hyperglycemic Effect of Khaya senegalensis Stem Bark Aqueous Extract in Wistar Rats. European Journal of Medicinal Plants. 2012 Jan-Mar; 2(1): 66-73.