Efficacy and safety of a polyherbal formulation in hemorrhoids.
| dc.contributor.author | Tripathi, Raakhi K | |
| dc.contributor.author | Bolegave, Somesh S | |
| dc.contributor.author | Shetty, Parvan A | |
| dc.contributor.author | Uchil, Dinesh A | |
| dc.contributor.author | Rege, Nirmala N | |
| dc.contributor.author | Chawda, Mukesh B | |
| dc.contributor.author | Rege, Sameer A | |
| dc.date.accessioned | 2016-02-22T03:50:16Z | |
| dc.date.available | 2016-02-22T03:50:16Z | |
| dc.date.issued | 2015-10 | |
| dc.description.abstract | Background: The medical management of hemorrhoids should include an integrated approach. This integrated approach can be achieved by polyherbal formulations containing anti-inflammatory, styptics, analgesics, and laxative effect which reduce inflammation, pain, and bleeding, and increase gastro-intestinal motility and soften stools. One such polyherbal kit is “Arshkeyt™, a 7 day kit,” which consists of oral tablets and powder along with topical cream. Objective: Efficacy and safety of Arshkeyt™, a 7 day kit, a marketed polyherbal formulation was evaluated in comparison with conventional therapy practiced in surgery outpatient departments. Materials and Methods: Patients (n = 90) with hemorrhoids were randomly allocated to receive either Arshkeyt™ or standard therapy (combination of oral Isabgul powder and 2% lidocaine gel) for 14 days. Assessment on the basis of rectal symptoms and proctoscopic examination was done on day 0, 7, and 14 to derive a “composite score” which ranged from 0 to 25 by a blinded evaluator. The primary endpoint was number of patients achieving composite score 0 at the end of therapy (day 14). Inter-group analysis was done using Chi-square test. Results: On day 14, the composite score of 0 was achieved in 15 patients of Arshkeyt™ group versus 6 patients receiving standard therapy. The symptoms and signs which showed significant improvement in Arshkeyt™ group compared to standard treatment group were the tenesmus (visual analog score) score (P = 0.047), anal sphincter spasm (P = 0.0495) and a decrease in the grade of hemorrhoids (P = 0.0205) on day 14. Arshkeyt™ was also more beneficial in case of bleeding hemorrhoids as compared to nonbleeding hemorrhoids (P < 0.05). The incidence of adverse drug reactions in both groups was comparable and no patient required any treatment for the same. Conclusion: “Arshkeyt™, a 7 day kit,” was effective in the treatment of hemorrhoids and had a good safety profile. | en_US |
| dc.identifier.citation | Tripathi Raakhi K, Bolegave Somesh S, Shetty Parvan A, Uchil Dinesh A, Rage Nirmala N, Chawda Mukesh B, Rage Sameer A. Efficacy and safety of a polyherbal formulation in hemorrhoids. Journal of Ayurveda and Integrative Medicine. 2015 Oct-Dec; 6(4): 225-232. | en_US |
| dc.identifier.issn | 0975-9476 | |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/173714 | |
| dc.language.iso | en | en_US |
| dc.source.uri | https://www.jaim.in/article.asp?issn=0975-9476;year=2015;volume=6;issue=4;spage=225;epage=232;aulast=Tripathi | en_US |
| dc.subject | Anal sphincter spasm, | en_US |
| dc.subject | isabgul | en_US |
| dc.subject | rectal bleeding | en_US |
| dc.subject | tenesmus | en_US |
| dc.subject | 2% lidocaine gel | en_US |
| dc.title | Efficacy and safety of a polyherbal formulation in hemorrhoids. | en_US |
| dc.type | Article | en_US |