Efficacy and safety of a polyherbal formulation in hemorrhoids.
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Date
2015-10
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Abstract
Background: The medical management of hemorrhoids should include an integrated approach. This integrated approach
can be achieved by polyherbal formulations containing anti-inflammatory, styptics, analgesics, and laxative effect which
reduce inflammation, pain, and bleeding, and increase gastro-intestinal motility and soften stools. One such polyherbal
kit is “Arshkeyt™, a 7 day kit,” which consists of oral tablets and powder along with topical cream. Objective: Efficacy
and safety of Arshkeyt™, a 7 day kit, a marketed polyherbal formulation was evaluated in comparison with conventional
therapy practiced in surgery outpatient departments. Materials and Methods: Patients (n = 90) with hemorrhoids were
randomly allocated to receive either Arshkeyt™ or standard therapy (combination of oral Isabgul powder and 2% lidocaine
gel) for 14 days. Assessment on the basis of rectal symptoms and proctoscopic examination was done on day 0, 7, and
14 to derive a “composite score” which ranged from 0 to 25 by a blinded evaluator. The primary endpoint was number of
patients achieving composite score 0 at the end of therapy (day 14). Inter-group analysis was done using Chi-square test.
Results: On day 14, the composite score of 0 was achieved in 15 patients of Arshkeyt™ group versus 6 patients receiving
standard therapy. The symptoms and signs which showed significant improvement in Arshkeyt™ group compared to standard
treatment group were the tenesmus (visual analog score) score (P = 0.047), anal sphincter spasm (P = 0.0495) and a
decrease in the grade of hemorrhoids (P = 0.0205) on day 14. Arshkeyt™ was also more beneficial in case of bleeding
hemorrhoids as compared to nonbleeding hemorrhoids (P < 0.05). The incidence of adverse drug reactions in both groups
was comparable and no patient required any treatment for the same. Conclusion: “Arshkeyt™, a 7 day kit,” was effective
in the treatment of hemorrhoids and had a good safety profile.
Description
Keywords
Anal sphincter spasm,, isabgul, rectal bleeding, tenesmus, 2% lidocaine gel
Citation
Tripathi Raakhi K, Bolegave Somesh S, Shetty Parvan A, Uchil Dinesh A, Rage Nirmala N, Chawda Mukesh B, Rage Sameer A. Efficacy and safety of a polyherbal formulation in hemorrhoids. Journal of Ayurveda and Integrative Medicine. 2015 Oct-Dec; 6(4): 225-232.