Characteristics and physiological role of surfactant-like particles secreted by entrocytes.
dc.contributor.author | Turan, Aasma | en_US |
dc.contributor.author | Gupta, Shiffalli | en_US |
dc.contributor.author | Mahmood, Akhtar | en_US |
dc.date.accessioned | 2009-05-28T11:56:42Z | |
dc.date.available | 2009-05-28T11:56:42Z | |
dc.date.issued | 2006-07-29 | en_US |
dc.description | 39 references. | en_US |
dc.description.abstract | Intestinal epithelium secretes novel unilamellar membranes having characteristics similar to lung surfactants and thus has been named Surfactant-like particles (SLP). The chemical analysis of the membranes revealed cholesterol/phospholipid molar ratio of 0.68-0.78, which is much distinct from that of the underlying microvillus membranes (1.34-1.49). The membrane contains 4-6 proteins with a molar weight of 30-120 kDa and is enriched with alkaline phosphatase, contains low amounts of disaccharidases but no Na+, K(+)-ATPase activity. The secretion of SLP is stimulated by fat feeding. Chronic ethanol ingestion also induces the formation of SLP in rat intestine. A number of physiological functions have been attributed to SLP, which include: (i) as a protective lubricant in intestinal lumen, (ii) a role in triacylglycerol transport, (iii) as a vehicle for the transport of luminal proteins into blood, (iv) as a stratum for the adhesion of microorganisms in intestinal lumen, and (v) a role in trans-signalling mechanism across the basolateral surface of enterocytes. | en_US |
dc.description.affiliation | Department of Biochemistry, Panjab University, Chandigarh 160 014, India. | en_US |
dc.identifier.citation | Turan A, Gupta S, Mahmood A. Characteristics and physiological role of surfactant-like particles secreted by entrocytes. Indian Journal of Experimental Biology. 2006 Jul; 44(7): 519-25 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/57413 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.asp | en_US |
dc.source.uri | https://nopr.niscair.res.in/bitstream/123456789/6539/1/IJEB%2044%287%29%20519-525.pdf | en_US |
dc.subject.mesh | Alkaline Phosphatase --metabolism | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Dietary Fats --administration & dosage | en_US |
dc.subject.mesh | Enterocytes --drug effects | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Intracellular Membranes --metabolism | en_US |
dc.subject.mesh | Lipoproteins --metabolism | en_US |
dc.subject.mesh | Phospholipids --metabolism | en_US |
dc.subject.mesh | Surface-Active Agents | en_US |
dc.title | Characteristics and physiological role of surfactant-like particles secreted by entrocytes. | en_US |
dc.type | Journal Article | en_US |
dc.type | Research Support, Non-U.S. Gov't | en_US |
dc.type | Review | en_US |
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