Characteristics and physiological role of surfactant-like particles secreted by entrocytes.

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dc.contributor.authorTuran, Aasmaen_US
dc.contributor.authorGupta, Shiffallien_US
dc.contributor.authorMahmood, Akhtaren_US
dc.date.accessioned2009-05-28T11:56:42Z
dc.date.available2009-05-28T11:56:42Z
dc.date.issued2006-07-29en_US
dc.description39 references.en_US
dc.description.abstractIntestinal epithelium secretes novel unilamellar membranes having characteristics similar to lung surfactants and thus has been named Surfactant-like particles (SLP). The chemical analysis of the membranes revealed cholesterol/phospholipid molar ratio of 0.68-0.78, which is much distinct from that of the underlying microvillus membranes (1.34-1.49). The membrane contains 4-6 proteins with a molar weight of 30-120 kDa and is enriched with alkaline phosphatase, contains low amounts of disaccharidases but no Na+, K(+)-ATPase activity. The secretion of SLP is stimulated by fat feeding. Chronic ethanol ingestion also induces the formation of SLP in rat intestine. A number of physiological functions have been attributed to SLP, which include: (i) as a protective lubricant in intestinal lumen, (ii) a role in triacylglycerol transport, (iii) as a vehicle for the transport of luminal proteins into blood, (iv) as a stratum for the adhesion of microorganisms in intestinal lumen, and (v) a role in trans-signalling mechanism across the basolateral surface of enterocytes.en_US
dc.description.affiliationDepartment of Biochemistry, Panjab University, Chandigarh 160 014, India.en_US
dc.identifier.citationTuran A, Gupta S, Mahmood A. Characteristics and physiological role of surfactant-like particles secreted by entrocytes. Indian Journal of Experimental Biology. 2006 Jul; 44(7): 519-25en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/57413
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/6539/1/IJEB%2044%287%29%20519-525.pdfen_US
dc.subject.meshAlkaline Phosphatase --metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDietary Fats --administration & dosageen_US
dc.subject.meshEnterocytes --drug effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshIntracellular Membranes --metabolismen_US
dc.subject.meshLipoproteins --metabolismen_US
dc.subject.meshPhospholipids --metabolismen_US
dc.subject.meshSurface-Active Agentsen_US
dc.titleCharacteristics and physiological role of surfactant-like particles secreted by entrocytes.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeReviewen_US
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