Evaluation of Nephroprotective Effect of Ethanolic Extract of Leaves of Aloe barbadensis against Gentamicin Induced Nephrotoxicity in Rats

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dc.contributor.authorShamim, Salmanen_US
dc.contributor.authorRana, M Aen_US
dc.contributor.authorArshad, Nen_US
dc.contributor.authorKumar, Amiten_US
dc.contributor.authorIslam, C Nen_US
dc.date.accessioned2019-11-16T07:27:36Z
dc.date.available2019-11-16T07:27:36Z
dc.date.issued2018-10
dc.description.abstractBackground: To evaluate the nephroprotective effect of ethanolic extract of leaves of Aloe barbadensis against gentamicin induced nephrotoxicity in albino rats. Methods: In the present study 24 albino rats of 120-150gm were taken and these rats were divided into four groups. Group I and II served as vehicle control and negative control groups respectively. While group III (EEAB150) and IV (EEAB300) served as treatment groups, which were treated with 150 and 300mg/kg/day of ethanolic extract of Aloe barbadensis, 1 hour before each dose of gentamicin administration for 8 days. On the 8th day of Gentamicin administration (80mg/kg/day, i.p) blood samples for BUN, serum creatinine, urine creatinine and total protein were taken while the rat kidneys for antioxidant assay and histology were obtained. Results: In group II nephrotoxicity was confirmed by significant elevation of BUN and Serum creatinine while urine creatinine and total protein is significantly decreased compared to group I , while in treatment groups III and IV there is significant attenuation of elevated BUN and S. creatinine while urine creatinine and total protein tends to increase compared to group II. Also, there was significant changes observed in antioxidant markers in the treatment groups III and IV. Improvement in renal function was also confirmed by histology of rat kidneys. Conclusion: Ethanolic extracts of leaves of Aloe barbadensis possess nephroprotective effect against gentamicin induced nephrotoxicity.en_US
dc.identifier.affiliationsPGT Final year, Department of Pharmacology, Katihar Medical College, Karim bagh, Katiharen_US
dc.identifier.affiliationsAssistant Professor, Department of Pharmacology, Katihar Medical College, Karim bagh, Katiharen_US
dc.identifier.affiliationsAssociate Professor, Department of Pharmacology, Katihar Medical College, Karim bagh, Katiharen_US
dc.identifier.affiliationsPGT Final year, Department of Pharmacology, Katihar Medical College, Karim bagh, Katiharen_US
dc.identifier.affiliationsProfessor, Department of Pharmacology, Katihar Medical College, Karim bagh, Katiharen_US
dc.identifier.citationShamim Salman, Rana M A, Arshad N, Kumar Amit, Islam C N. Evaluation of Nephroprotective Effect of Ethanolic Extract of Leaves of Aloe barbadensis against Gentamicin Induced Nephrotoxicity in Rats. International Archives of BioMedical and Clinical Research. 2018 Oct-Dec; 4(4): 70-73en_US
dc.identifier.issn2454-9894
dc.identifier.issn2454-9886
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/184519
dc.languageenen_US
dc.publisherIbn Sina Academy of Medieval Medicine & Sciencesen_US
dc.relation.issuenumber4en_US
dc.relation.volume4en_US
dc.source.urihttps://doi.org/10.21276/iabcr.2018.4.4.20en_US
dc.subjectNephrotoxicityen_US
dc.subjectAminoglycosidesen_US
dc.subjectGentamicinen_US
dc.subjectAloe barabdensisen_US
dc.subjectOxidative stressen_US
dc.titleEvaluation of Nephroprotective Effect of Ethanolic Extract of Leaves of Aloe barbadensis against Gentamicin Induced Nephrotoxicity in Ratsen_US
dc.typeJournal Articleen_US
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