Auto antibodies against oxidized low density lipoproteins and lipid peroxidation in patients with essential hypertension
Loading...
Date
2010-05
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Lipid peroxidation has been suggested to play a key role in the oxidative
modification of LDL (oxd-LDL) which stimulate the production of auto antibodies by Bcells
and anti-oxd LDL antibodies are produced. These antibodies could represent a
biological marker of oxidative stress and serve as markers of atherosclerosis. Essential
hypertension is a major risk factor for atherosclerosis, recently border line hypertension
also has been shown to be a risk factor for atherosclerosis. The aim of this study is to
examine the correlation between oxd -LDL antibodies and lipid peroxidation in patient
with essential hypertension. Blood samples were collected from patients with essential
hypertension (n=155) and healthy individuals (n=160) levels of Malonaldihyde (MDA),
Total cholesterol, Triglycerides, HDL and LDL were estimated by spectrophotometry
and levels of Oxd- LDL antibodies were obtained by ELISA. Plasma levels of MDA,
anti-oxdLDL antibodies, Total cholesterol and LDL Cholesterol is higher in patients
than those in controls. Among patients concentration of MDA, total cholesterol and LDL
cholesterol were not significantly different, however the concentration of anti-oxd LDL
were higher in essential hypertensive patients (p=0.003). Significant positive correlation
was observed between plasma levels of MDA, total cholesterol, LDL cholesterol and the
concentration of anti-oxdLDL in patients but not in the controls. In conclusion High
concentrations of anti-oxdLDL and MDA suggest an increase in oxidative stress that
would contribute to the development of atherosclerosis. The observed correlation of
MDA with anti-oxdLDL indicates the relationship between free radicals and
atherosclerosis in essential hypertension.
Description
Keywords
Oxidized LDL auto antibodies, Malondialdehyde, atherosclerosis, essential hypertension
Citation
Ramalingam K, Santha K, Sethupathy S, Kumar R Vinoth. Auto antibodies against oxidized low density lipoproteins and lipid peroxidation in patients with essential hypertension. International Journal of Applied Biology and Pharmaceutical Technology. 2010 May-Jul; 1(1): 11-20.