Contraceptive potential of an antiprogestin ZK 98.734: reversal of ZK 98.734--induced blockade of folliculogenesis with FSH and LH and their differential effects in bonnet monkeys.

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dc.contributor.authorPuri, C Pen_US
dc.contributor.authorKatkam, R Ren_US
dc.contributor.authorVadigoppula, A Den_US
dc.contributor.authorGopalakrishnan, Ken_US
dc.contributor.authorElger, W Aen_US
dc.contributor.authorBillimoria, F Ren_US
dc.contributor.authorPatil, R Ken_US
dc.date.accessioned2009-05-28T14:58:27Z
dc.date.available2009-05-28T14:58:27Z
dc.date.issued1992-11-01en_US
dc.description.abstractStudies were undertaken in adult bonnet monkeys to investigate whether treatment with an antiprogestin ZK 98.734 at weekly intervals, starting from day one of menstrual cycle, could arrest ovulation and also to determine if ZK 98.734 induced blockade of ovulation could be reversed with gonadotropins. Adult animals have ovulatory menstrual cycles of normal duration were treated at weekly intervals with ZK 98.734 (25 mg/dose, sc, oil base) for 10 consecutive weeks and its effects on serum levels of estradiol, bioactive LH and progesterone, and endometrial histology were investigated. Following treatment with the antiprogestin they were treated with hMG or hFSH alone. Ovulation was blocked during treatment period in all the animals (n = 14). Typical follicular phase rise in estradiol levels was inhibited, mid cycle surge in the levels of bioactive LH was abolished and serum progesterone levels remained below 1 ng/ml throughout the treatment period. However, prolonged treatment had no significant effect on the basal levels of estradiol which were around 50 pg/ml. ZK 98.734 also had no significant effect on cortisol levels. In animals (n = 4) followed for recovery after the last dose, the treatment cycle length was increased to 117.8 + 6.8 days. In three animals the treatment cycles were anovulatory, whereas in one delayed ovulation with luteal insufficiency was observed. The endometrium had become atrophic. Treatment with hMG (Pergonal: 35 I.U. hLH and 35 I.U. hFSH) or hFSH (Metrodin, 35 I.U.) for 7 consecutive days initiated folliculogenesis and the animals ovulated either spontaneously or after a single im injection of hCG (100 I.U.) on day 8 in ZK 98.734 treated animals.(ABSTRACT TRUNCATED AT 250 WORDS)en_US
dc.description.affiliationInstitute for Research in Reproduction (ICMR), Bombay, India.en_US
dc.identifier.citationPuri CP, Katkam RR, Vadigoppula AD, Gopalakrishnan K, Elger WA, Billimoria FR, Patil RK. Contraceptive potential of an antiprogestin ZK 98.734: reversal of ZK 98.734--induced blockade of folliculogenesis with FSH and LH and their differential effects in bonnet monkeys. Indian Journal of Experimental Biology. 1992 Nov; 30(11): 987-95en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61395
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshContraceptive Agents, Female --pharmacologyen_US
dc.subject.meshEstradiol --blooden_US
dc.subject.meshEstrenes --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollicle Stimulating Hormone --pharmacologyen_US
dc.subject.meshLuteinizing Hormone --blooden_US
dc.subject.meshMacaca radiataen_US
dc.subject.meshMenstrual Cycle --drug effectsen_US
dc.subject.meshOvarian Follicle --cytologyen_US
dc.subject.meshProgesterone --blooden_US
dc.subject.meshProgestins --antagonists & inhibitorsen_US
dc.titleContraceptive potential of an antiprogestin ZK 98.734: reversal of ZK 98.734--induced blockade of folliculogenesis with FSH and LH and their differential effects in bonnet monkeys.en_US
dc.typeJournal Articleen_US
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