Plant-Derived Phenolic Antioxidants and Cancer Prevention
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Date
2010-04-07
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Thai Cancer Journal
Abstract
Oxidative stress imposed by reactive oxygen species (ROS) plays a crucial role in the pathophysiology associated with cancer and atherosclerosis. The ROS-induced development of cancer involves malignant transformation due to altered gene expression through epigenetic mechanisms as well as DNA mutations. The phenolic antioxidants play an important role in the chemoprevention of diseases especially cancer by reduced excess ROS. This article reviews the classification of major phenolic compound such as, phenolic acids and flavonoids, and the role of phenolic compound in cancer prevention. Future studies are not only elucidated mechanism related to direct antioxidant of phenolic compounds, but also to their ability to bind cellular receptors and transporters and influence gene expression, cell signaling, and cell adhesion.
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Thai Cancer Journal; Vol.29 No.3 July-September 2009; 126-134