Renal function impairment in Hypothyroidism.
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Date
2013
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Abstract
Background: Hypothyroidism is an important public health problem in Bangladesh. It is
associated with increased risk for atherosclerosis and other complications. The frank
development of hypothyroidism is associated with metabolic derangements including
dyslipidemia- which is an etiopathologic factor for development of renal impairment. This
study was to evaluate whether hypothyroidism is associated with impaired renal function.
Methods: Using a cross sectional analytical study design, a total of 111 subjects attending
Out Patient Department, Center for Nuclear Medicine and Ultrasound, Bogra Medical
College during January 2007 to December 2007 were included purposively. Eighty newly
diagnosed hypothyroid patients (Group I) and 31 healthy adults (Group II) were enrolled
in this study. Serum thyroid stimulating hormone and serum free thyroxine were assayed
by radioimmunoassay. Serum fasting lipid profile, serum creatinine and serum uric acid
were estimated by enzymatic colorimetric method. Estimated GFR was calculated using
MDRD equation. Results: The mean (±SD) age of in Group I and Group II were 35.59
(±6.91) and 37.35 (±2.78) years and were comparable. In Group I, there were 66
females and 14 males. In Group II, there were 16 females and 15 males. The mean BMI
was 25.49 ±2.17 kg/m2 in Group I and 24.24 ±1.99 kg/m2 in Group II. The mean
(±SD) Serum total-cholesterol, LDL- cholesterol and tryacylglycerol in Group I were
significantly higher than that in Group II. Serum HDL cholesterol in Group I was
significantly lower than that in Group II (p<0.001). The mean (±SD) serum creatinine
was significantly higher in Group I than Group II (P<0.001). The estimated glomerular
filtration rate (eGFR) was lower in Group I compared to Group II (p=0.011). In Group I
(Hypothyroid), there were significant correlations of BMI, S Total-Cholesterol, S HDLCholesterol,
S LDL-Cholesterol, S triglycerides and S creatinine with serum TSH level.
In Group I (Hypothyroid), there were significant positive correlations of BMI and TSH
with serum creatinine. Conclusions: Hypothyroidism is associated with dyslipidemia,
hyperuricemia and impaired renal function. Therefore, patients presenting with these
biochemical abnormalities are recommended to be investigated for hypothyroidism and
vice versa.
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Keywords
Renal function and Hypothyroidism
Citation
Chaudhury H S, Raihan K K, Uddin M N, Ansari S M, Hasan M, Ahmed M, Kabir M F, Hoque M Z. Renal function impairment in Hypothyroidism. Bangladesh Journal of Medical Biochemistry. 2013; 6(1): 19-25.