Evaluation of Vitamin D Status in Children with Nephrotic Syndrome in Remission in a Tertiary Care Hospital of North India

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dc.contributor.authorBadyal, Ashimaen_US
dc.contributor.authorKumar, Koushalen_US
dc.date.accessioned2020-10-16T09:00:57Z
dc.date.available2020-10-16T09:00:57Z
dc.date.issued2020-04
dc.description.abstractChildhood nephrotic syndrome (NS) is characterized by massive proteinuria, hypoalbuminemia, hyperlipidemiaassociated with peripheral edema. Children with NS lose 25-OH vitamin D binding protein in urine, and canhave low blood levels of this metabolite. The present hospital-based study was carried out on a total of 50children with nephrotic syndrome who are in remission, in the age group of 1-15 years of either gender,attending to our pediatric nephrology clinic. 46% had clear deficiency of vitamin D, while insufficiency waspresent in 28% and normal levels in only 26% of patients. There was significant difference (p<0.05) in 25-OHvitamin D levels between frequent relapsers (FR) as compared to infrequent relapsers (IR) and first episode ofnephrotic syndrome. Hypocalcemia was present in 86% of patients, hypophosphatemia in 10% of patients,hyperphosphatemia in 50% and raised alkaline phosphatase in 36% of patients. Strong positive correlation isobserved between serum calcium and vitamin D levels (r=0.720; p<0.001) and moderate negative correlationbetween phosphorous and vitamin D levels (r= -0.577; p<0.001, but insignificant relation between vitamin Dand alkaline phosphate levels (r= -0.248; p<0.082). It is concluded that vitamin D deficiency is commonamong children with nephrotic syndrome even after remission of proteinuria. There exists a strong positivecorrelation between serum calcium and vitamin D levels.en_US
dc.identifier.affiliationsDepartment of Biochemistry and Paediatrics*, Govt. Medical College, Jammu, J&K- Indiaen_US
dc.identifier.citationBadyal Ashima, Kumar Koushal. Evaluation of Vitamin D Status in Children with Nephrotic Syndrome in Remission in a Tertiary Care Hospital of North India. JK Science Journal of Medical Education and Research. 2020 Apr; 2020 Apr: 92-95en_US
dc.identifier.issn0972-1177
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/211019
dc.languageenen_US
dc.publisherJK Scienceen_US
dc.relation.issuenumber2en_US
dc.relation.volume22en_US
dc.source.urihttps://www.jkscience.org/archives/volume222/11-Original%20Article.pdfen_US
dc.subjectNephrotic Syndromeen_US
dc.subjectVitamin Den_US
dc.subjectSerum Calciumen_US
dc.subjectPhosphorusen_US
dc.subjectAlkaline Phosphateen_US
dc.titleEvaluation of Vitamin D Status in Children with Nephrotic Syndrome in Remission in a Tertiary Care Hospital of North Indiaen_US
dc.typeJournal Articleen_US
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