Antimutagenicity against Urethane of Mangosteen, Durian Products and Their Combinations in Somatic Mutation and Recombination Test

Simple item page
dc.contributor.authorP. Jitwiriyathamen_US
dc.contributor.authorKaew Kangsadalampaien_US
dc.date.accessioned2011-02-22T08:49:04Z
dc.date.available2011-02-22T08:49:04Z
dc.date.created2010-03-18en_US
dc.date.issued2010-03-18en_US
dc.description.abstractLyophilized durian meat, lyophilized mangosteen meat, durian chip, durian paste and the combinations (1:1, 1:2 and 2:1) of each durian product and mangosteen were determined for their effect on urethane induced somatic mutation and recombination in  Drosophila melanogaster. The three-day old trans-heterozygous (mwh flr+/mwh TM3) larvae were transferred to an experimental medium (substituted each sample for 25, 50, 75 or 100% of corn flour) that had urethane (20 mM). We analyzed for the occurrence of mutant spots of the wings from the surviving flies and found that most samples enhanced the mutagenicity of urethane with different degree. The enhancement of urethane mutagenicity might involve in the phenomenon that the chemical compounds in the samples induced the activity of mixed function oxidases and saturation of enzymatic systems involved in the DNA repair pathways since the amount of each sample incorporated into the fly medium seemed to be very high. The results as such indicated that high consumption of durian and mangosteen should be with caution since it might enhance the mutagenicity of the compounds contaminated in our daily food. However, we surprisingly found that the combination of durian paste and mangosteen (2:1) had the highest antioxidant activity (determined with DPPH scavenging capacity and ferric reducing antioxidant power assays) as well as the content of phenolic compounds (determined with Folin-Ciocalteu reagent) while durian chip contained the least antioxidant and phenolic compounds.en_US
dc.identifier.citationThai Journal of Toxicology - วารสารพิษวิทยาไทย; Vol.23 No.2 (Special issue) November 2008; 117-125en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/132619
dc.language.isoen_USen_US
dc.publisherThai Journal of Toxicology - วารสารพิษวิทยาไทยen_US
dc.rightsThai Society of Toxicology, Bangkok, Thailanden_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/TJT/issue/archiveen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/TJT/article/view/2298en_US
dc.titleAntimutagenicity against Urethane of Mangosteen, Durian Products and Their Combinations in Somatic Mutation and Recombination Testen_US
dc.typeResearch Articlesen_US
Files
Collections
Thai Journal of Toxicology - วารสารพิษวิทยาไทย