Multidrug Resistant Acinetobacter in Patient with Ventilator Associated Pneumonia: Review Article.
Date
2019-07
Journal Title
Journal ISSN
Volume Title
Publisher
Krishna Institute of Medical Sciences University
Abstract
Acinetobacter is a complex genus, with multiple species. Acinetobacterspecies are the common etiology of nosocomial infections, principally nosocomial pneumonia catheter-associated bacteremia and urinary tract infections. Multidrug Resistant (MDR) Ventilator Associated Pneumonia (VAP) by Acinetobacter spp is increasingly reported from different parts of the world. Transmission of Acinetobacter is aid by the organism's environmental stubbornness, resistance to desiccation and evasion of host immunity. The virulence properties demonstrated by Acinetobacter spp. is primarily by evasion of rapid clearance by the immune system. The capsular polysaccharide is a critical virulence factor that enables immune evasion and lipopolysaccharide triggers septic shock. Conversely, the primary factor of clinical outcome is antibiotic resistance. Acinetobacter spp. has become a discreditable threat for patients on mechanical ventilation. Considering high rate of antibiotic resistance, new preventive and therapeutic alternative pproach for MDR Acinetobacter spp. infections are urgently needed. Worldwide drug esistance in Acinetobacter baumannii is growing. This review article is emphasised on incidence of VAPdue to MDR Acinetobacter, phenotypes, genotypes, associated risk factors and preventive strategy
Description
Keywords
Acinetobacter spp, Ventilator Associated Pneumonia, Mechanical Ventilation, Multidrug Resistant, Phenotypes, Genotypes
Citation
Patil Harsha V., Mohite Shivaji T., Patil Virendra C.. Multidrug Resistant Acinetobacter in Patient with Ventilator Associated Pneumonia: Review Article.. Journal of Krishna Institute of Medical Sciences University. 2019 Jul; 8(3): 1-18