Heart rate variability responses to standing are attenuated in drug naive depressed patients.

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dc.contributor.authorPradeep, Johnson
dc.contributor.authorSambashivaiah, Sucharita
dc.contributor.authorThomas, Tinku
dc.contributor.authorRadhakrishnan, Rajiv
dc.contributor.authorVaz, Mario
dc.contributor.authorSrinivasan, Krishnamachari
dc.date.accessioned2013-04-15T05:02:11Z
dc.date.available2013-04-15T05:02:11Z
dc.date.issued2012-07
dc.description.abstractDepression has been linked to altered cardiac autonomic regulation. Previous studies have been inconsistent in terms of measurement of heart rate variability (HRV), selection of depressed patients with cardiac disorders and not controlling for co-morbid conditions such as substance use and anxiety disorders. The objective of this study is to compare the effect of posture on spectral measures of HRV in drug naive healthy patients with major depression with age and gender matched healthy controls. Spectral measures of HRV in supine position and with active standing were obtained (using Task force recommendations). Repeated measure ANOVA revealed an attenuated response in HRV parameters (HF normalized units & LH/HF ratio) to active standing in depressed subjects compared to healthy controls. We conclude that there is an impaired parasympathetic modulation in response to physiological maneuver (orthostatic challenge) in drug naive subjects with major depression (co-morbid medical or psychiatric conditions) compared to healthy controls.en_US
dc.identifier.citationPradeep Johnson, Sambashivaiah Sucharita, Thomas Tinku, Radhakrishnan Rajiv, Vaz Mario, Srinivasan Krishnamachari. Heart rate variability responses to standing are attenuated in drug naive depressed patients. Indian Journal of Physiology and Pharmacology. 2012 Jul-Sept; 56(3): 213-221.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/146111
dc.language.isoenen_US
dc.source.urihttps://www.ijpp.com/IJPP%20archives/2012_56_3_%20July%20-%20Sep/213-221.pdfen_US
dc.subjectmajor depressionen_US
dc.subjectautonomic nervous systemen_US
dc.subjectheart rate variabilityen_US
dc.subjectpostureen_US
dc.subjectparasympatheticen_US
dc.subjectsympathovagal balanceen_US
dc.titleHeart rate variability responses to standing are attenuated in drug naive depressed patients.en_US
dc.typeArticleen_US
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