Heart rate variability responses to standing are attenuated in drug naive depressed patients.
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Date
2012-07
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Abstract
Depression has been linked to altered cardiac autonomic
regulation. Previous studies have been inconsistent in terms of
measurement of heart rate variability (HRV), selection of depressed patients
with cardiac disorders and not controlling for co-morbid conditions such as
substance use and anxiety disorders. The objective of this study is to
compare the effect of posture on spectral measures of HRV in drug naive
healthy patients with major depression with age and gender matched healthy
controls. Spectral measures of HRV in supine position and with active
standing were obtained (using Task force recommendations). Repeated
measure ANOVA revealed an attenuated response in HRV parameters (HF
normalized units & LH/HF ratio) to active standing in depressed subjects
compared to healthy controls. We conclude that there is an impaired
parasympathetic modulation in response to physiological maneuver
(orthostatic challenge) in drug naive subjects with major depression
(co-morbid medical or psychiatric conditions) compared to healthy controls.
Description
Keywords
major depression, autonomic nervous system, heart rate variability, posture, parasympathetic, sympathovagal balance
Citation
Pradeep Johnson, Sambashivaiah Sucharita, Thomas Tinku, Radhakrishnan Rajiv, Vaz Mario, Srinivasan Krishnamachari. Heart rate variability responses to standing are attenuated in drug naive depressed patients. Indian Journal of Physiology and Pharmacology. 2012 Jul-Sept; 56(3): 213-221.