Possible nitric oxide mechanism in the protective effect of hesperidin against ischemic reperfusion cerebral injury in rats.

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dc.contributor.authorGaur, Vaibhav
dc.contributor.authorAggarwal, Aditi
dc.contributor.authorKumar, Anil
dc.date.accessioned2013-02-15T10:46:59Z
dc.date.available2013-02-15T10:46:59Z
dc.date.issued2011-08
dc.description.abstractStroke is the third leading cause of death and disability around the globe. The aim of the present investigation was to evaluate the protective effect of hesperidin and its nitric oxide mechanism against cerebral ischemia reperfusion injury. Bilateral common carotid artery occlusion for 30 min followed by 24 h reperfusion was given to induce ischemia in rats. Animals were pretreated with hesperidin (50 and 100 mg/kg, po) for 7 days. Various behavioural tests, oxidative stress parameters, endogenous antioxidant system, antioxidant enzyme activity and mitochondrial enzyme complex (I, II, III and IV) dysfunctions in cortex and striatum were assessed subsequently. Hesperidin (50 and 100 mg/kg) significantly improved neurobehavioral alterations (neurological score, locomotor activity, resistance to lateral push and hanging wire latency), attenuated oxidative damage, restored antioxidant and mitochondrial complex enzyme activities in cortex and in striatum regions of the brain as compared to their respective controls. L-arginine (100 mg/kg) or L-NAME (10 mg/kg) pretreatment with lower dose of hesperidin (50 mg/kg) significantly reversed or potentiated its protective effect, respectively which was significant as compared to hesperidin (50 mg/kg). The results highlight the involvement of nitric oxide mechanism in the protective effect of hesperidin against ischemia reperfusion injury induced alterations.en_US
dc.identifier.citationGaur Vaibhav, Aggarwal Aditi, Kumar Anil. Possible nitric oxide mechanism in the protective effect of hesperidin against ischemic reperfusion cerebral injury in rats. Indian Journal of Experimental Biology. 2011 Aug; 49(8): 609-618.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/145169
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/12526en_US
dc.subjectBilateral common carotid artery occlusionen_US
dc.subjectHesperidinen_US
dc.subjectIschemiaen_US
dc.subjectOxidative stressen_US
dc.subjectRespiratory enzyme activityen_US
dc.subjectStrokeen_US
dc.titlePossible nitric oxide mechanism in the protective effect of hesperidin against ischemic reperfusion cerebral injury in rats.en_US
dc.typeArticleen_US
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