Cancer screening with whole-body PET/CT for healthy asymptomatic people in Japan: re-evaluation of its test validity and radiation exposure.

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dc.contributor.authorGhotbi, Naderen_US
dc.contributor.authorIwanaga, Masakoen_US
dc.contributor.authorOhtsuru, Akiraen_US
dc.contributor.authorOgawa, Yojien_US
dc.contributor.authorYamashita, Shunichien_US
dc.date.accessioned2009-05-27T17:44:58Z
dc.date.available2009-05-27T17:44:58Z
dc.date.issued2007-01-05en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractThe use of Positron Emission Tomography (PET) or PET/CT for voluntary cancer screening of asymptomatic individuals is becoming common in Japan, though the utility of such screening is still controversial. This study estimated the general test validity and effective radiation dose for PET/CT cancer screening of healthy Japanese people by evaluating four standard indices (sensitivity, specificity, positive/negative predictive values), and predictive values with including prevalence for published literature and simulation-based Japanese data. CT and FDG-related dosage data were gathered from the literature and then extrapolated to the scan parameters at a model PET center. We estimated that the positive predictive value was only 3.3% in the use of PET/CT for voluntary cancer screening of asymptomatic Japanese individuals aged 50-59 years old, whose average cancer prevalence was 0.5%. The total effective radiation dose of a single whole-body PET/CT scan was estimated to be 6.34 to 9.48 mSv for the average Japanese individual, at 60 kg body weight. With PET/CT cancer screening in Japan, many healthy volunteers screened as false positive are exposed to at least 6.34 mSv without getting any real benefit. More evaluation concerning the justification of applying PET/CT for healthy people is necessary.en_US
dc.description.affiliationTakashi Nagai Memorial International Hibakusha Medical Center, Nagasaki University Hospital, Nagasaki City, Japan.en_US
dc.identifier.citationGhotbi N, Iwanaga M, Ohtsuru A, Ogawa Y, Yamashita S. Cancer screening with whole-body PET/CT for healthy asymptomatic people in Japan: re-evaluation of its test validity and radiation exposure. Asian Pacific Journal of Cancer Prevention. 2007 Jan-Mar; 8(1): 93-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37808
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshEnvironmental Exposureen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorodeoxyglucose F18 --diagnostic useen_US
dc.subject.meshHumansen_US
dc.subject.meshJapan --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMass Screening --methodsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasms --radionuclide imagingen_US
dc.subject.meshPositron-Emission Tomographyen_US
dc.subject.meshRadiation Dosageen_US
dc.subject.meshRadiopharmaceuticals --diagnostic useen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshTomography, X-Ray Computeden_US
dc.subject.meshWhole Body Imagingen_US
dc.titleCancer screening with whole-body PET/CT for healthy asymptomatic people in Japan: re-evaluation of its test validity and radiation exposure.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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