Comparative evaluation of the antioxidant capacity of ferulic acid and synthesized propionyl ferulate

Simple item page
dc.contributor.authorAdeyemi, Oluyomi Stephenen_US
dc.contributor.authorAyonote, Divine Ayebakuroen_US
dc.contributor.authorOluwakemi, Josephine Awakanen_US
dc.contributor.authorOlubunmi, Atolanien_US
dc.contributor.authorOpeyemi, Adejumoen_US
dc.contributor.authorAdewole, Ibrahimen_US
dc.contributor.authorDamilare, Rotimien_US
dc.contributor.authorGaber, El-Saber Batihaen_US
dc.contributor.authorJohn, Olusegun Ojediranen_US
dc.date.accessioned2020-10-16T08:56:56Z
dc.date.available2020-10-16T08:56:56Z
dc.date.issued2020-05
dc.description.abstractFerulic acid (FA) is a polyphenolic compound with demonstrated antioxidant capacity. In this study, propionylferulate (PF) was synthesized and characterized using melting point, ultraviolet spectroscopy, Fourier-transforminfrared spectroscopy, and mass spectrometry. The propionyl ferulate was comparatively evaluated for antioxidantpotential which included the ability to quench reactive species of 2,2-diphenyl-2-picrazyl-hydrazyl (DPPH), hydroxyl,nitric oxide, and superoxide anion. In addition, the total antioxidant capacity and membrane stabilizing properties ofthe ferulate were determined. Comparatively, the spectroscopically characterized PF showed superior scavengingcapacity for the DPPH, hydroxyl, and nitric oxide free radicals when compared to FA. On the contrary, PF showed apoor scavenging capacity for superoxide anion radicals. Furthermore, PF showed little or no potential for membranestability. In conclusion, the data suggest that structurally modifying FA to PF improved the antioxidant capacity forseveral free radicals.en_US
dc.identifier.affiliationsDepartment of Biochemistry, Medicinal Biochemistry, Nanomedicine & Toxicology Laboratory, Landmark University, PMB 1001, Omu-Aran – 251101, Nigeriaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Medicinal Biochemistry, Nanomedicine & Toxicology Laboratory, Landmark University, PMB 1001, Omu-Aran – 251101, Nigeriaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Medicinal Biochemistry, Nanomedicine & Toxicology Laboratory, Landmark University, PMB 1001, Omu-Aran – 251101, Nigeriaen_US
dc.identifier.affiliationsDepartment of Chemistry, University of Ilorin, PMB 1515, Ilorin, Nigeriaen_US
dc.identifier.affiliationsDepartment of Chemistry, University of Ilorin, PMB 1515, Ilorin, Nigeriaen_US
dc.identifier.affiliationsDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Egypt.en_US
dc.identifier.affiliationsDepartment of Agricultural & Biosystem Engineering, Landmark University, PMB 1001, Omu-Aran – 251101, Nigeriaen_US
dc.identifier.citationAdeyemi Oluyomi Stephen, Ayonote Divine Ayebakuro, Oluwakemi Josephine Awakan, Olubunmi Atolani, Opeyemi Adejumo, Adewole Ibrahim, Damilare Rotimi, Gaber El-Saber Batiha, John Olusegun Ojediran. Comparative evaluation of the antioxidant capacity of ferulic acid and synthesized propionyl ferulate. Journal of Applied Pharmaceutical Science. 2020 May; 2020 May: 097-103en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210754
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber5en_US
dc.relation.volume10en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2020.10513en_US
dc.subjectAntioxidantsen_US
dc.subjectfood additivesen_US
dc.subjectmedicinal chemistryen_US
dc.subjectmedicinal biochemistryen_US
dc.subjectnatural products.en_US
dc.titleComparative evaluation of the antioxidant capacity of ferulic acid and synthesized propionyl ferulateen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
japs2020v10n5p097.pdf
Size:
25.47 MB
Format:
Adobe Portable Document Format
Download
Collections
Journal of Applied Pharmaceutical Science (JAPS)