Comparative evaluation of the antioxidant capacity of ferulic acid and synthesized propionyl ferulate
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Date
2020-05
Journal Title
Journal ISSN
Volume Title
Publisher
Open Science Publishers LLP
Abstract
Ferulic acid (FA) is a polyphenolic compound with demonstrated antioxidant capacity. In this study, propionylferulate (PF) was synthesized and characterized using melting point, ultraviolet spectroscopy, Fourier-transforminfrared spectroscopy, and mass spectrometry. The propionyl ferulate was comparatively evaluated for antioxidantpotential which included the ability to quench reactive species of 2,2-diphenyl-2-picrazyl-hydrazyl (DPPH), hydroxyl,nitric oxide, and superoxide anion. In addition, the total antioxidant capacity and membrane stabilizing properties ofthe ferulate were determined. Comparatively, the spectroscopically characterized PF showed superior scavengingcapacity for the DPPH, hydroxyl, and nitric oxide free radicals when compared to FA. On the contrary, PF showed apoor scavenging capacity for superoxide anion radicals. Furthermore, PF showed little or no potential for membranestability. In conclusion, the data suggest that structurally modifying FA to PF improved the antioxidant capacity forseveral free radicals.
Description
Keywords
Antioxidants, food additives, medicinal chemistry, medicinal biochemistry, natural products.
Citation
Adeyemi Oluyomi Stephen, Ayonote Divine Ayebakuro, Oluwakemi Josephine Awakan, Olubunmi Atolani, Opeyemi Adejumo, Adewole Ibrahim, Damilare Rotimi, Gaber El-Saber Batiha, John Olusegun Ojediran. Comparative evaluation of the antioxidant capacity of ferulic acid and synthesized propionyl ferulate. Journal of Applied Pharmaceutical Science. 2020 May; 2020 May: 097-103