Regulation of red cell acetylcholinesterase activity in diabetes mellitus.

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dc.contributor.authorSuhail, Men_US
dc.contributor.authorRizvi, S Ien_US
dc.date.accessioned2009-05-28T14:53:24Z
dc.date.available2009-05-28T14:53:24Z
dc.date.issued1990-03-01en_US
dc.description.abstractDespite the fact that the significance of red cell membrane acetylcholinesterase (AChE) is unknown, this enzyme of red cell assumes importance since many of its properties have been found to be similar to purified enzyme form of brain tissues. Our investigations on the effect of insulin-dependent diabetes mellitus on red cell AChE revealed that the activity of this enzyme is significantly decreased in diabetes. Insulin treatment restored the activity to the normal level. Solubilization of normal, diabetic and insulin treated diabetic red cell membranes with Triton X-100 (0.2% v/v) caused a general decline in AChE activity, however the per cent decline in activity of diabetic enzyme was lower as compared to normal and insulin treated conditions. From our results it is inferred that the decreased red cell AChE activity in diabetes is due to lesser number of active enzyme molecules and also due to altered membrane microenvironment.en_US
dc.description.affiliationDepartment of Biochemistry, University of Allahabad, India.en_US
dc.identifier.citationSuhail M, Rizvi SI. Regulation of red cell acetylcholinesterase activity in diabetes mellitus. Indian Journal of Experimental Biology. 1990 Mar; 28(3): 234-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61287
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAcetylcholinesterase --metabolismen_US
dc.subject.meshAdulten_US
dc.subject.meshDetergentsen_US
dc.subject.meshDiabetes Mellitus, Type 1 --drug therapyen_US
dc.subject.meshErythrocyte Membrane --enzymologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin --therapeutic useen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOctoxynolen_US
dc.subject.meshPolyethylene Glycolsen_US
dc.titleRegulation of red cell acetylcholinesterase activity in diabetes mellitus.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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