Neuropharmacological studies on Panax ginseng.

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dc.contributor.authorMitra, S Ken_US
dc.contributor.authorChakraborti, Aen_US
dc.contributor.authorBhattacharya, S Ken_US
dc.date.accessioned2009-05-28T13:21:47Z
dc.date.available2009-05-28T13:21:47Z
dc.date.issued1996-01-01en_US
dc.description.abstractPanax ginseng root powder is extensively used in the Far East for a wide variety of clinical ailments and to improve general physical and mental wellbeing. It is now also being used in the Occident because of the adaptogenic activity of the plant. The present investigation was conducted to evaluate the neurophamacological profile of activity of P. ginseng (ginseng), since the available data were meagre and often controversial. Ginseng had a complex profile of activity, sometimes difficult to reconcile on the available neurochemical reports on the plant. Thus, it did not appear to affect pentobarbitone sleep induction or spontaneous motor activity but potentiated amphetamine-induced increase in motility. However, ginseng attenuated the other effects of amphetamine, namely, stereotypy and lethality in aggregated mice. The drug exhibited antinociceptive activity and potentiated the antinociceptive effects of both pentazocine and aspirin. Haloperidol catalepsy was potentiated while the behavioural responses of 5-hydroxytryptophan (5-HTP) and L-DOPA were both attenuated. Ginseng had no anticonvulsant action, nor did it potentiate the anticonvulsant effects of phenobarbitone and diazepam. The drug had per se hyperthermic effect and attenuated the hypothermic response of reserpine and 5-HTP induced hyperthermia. Ginseng exhibited significant aggression-inhibiting effect in doses which had no significant effect on spontaneous motility. The results have been discussed on the neurotransmitter function basis of the experimental paradigms and the likely effect of ginseng on these actions.en_US
dc.description.affiliationDepartment of Pharmacology, Banaras Hindu University, Varanasi, India.en_US
dc.identifier.citationMitra SK, Chakraborti A, Bhattacharya SK. Neuropharmacological studies on Panax ginseng. Indian Journal of Experimental Biology. 1996 Jan; 34(1): 41-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59309
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBehavior, Animal --drug effectsen_US
dc.subject.meshDrugs, Chinese Herbal --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshNervous System --drug effectsen_US
dc.subject.meshPanaxen_US
dc.subject.meshPlants, Medicinalen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.titleNeuropharmacological studies on Panax ginseng.en_US
dc.typeJournal Articleen_US
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