Associated Risk Factors and Seroprevalence of Hepatitis B among Pregnant Women Attending Antenatal Clinic in a Rural Setting of Cameroon (Penka-Michel)

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dc.contributor.authorLaure, Brigitte Kouitcheu Mabekuen_US
dc.contributor.authorTchakounte, Constantinen_US
dc.contributor.authorFlaurant, Tchouangueu Thibauen_US
dc.contributor.authorEtoa, Francois-Xavieren_US
dc.date.accessioned2020-10-16T08:52:13Z
dc.date.available2020-10-16T08:52:13Z
dc.date.issued2019-03
dc.description.abstractBackground: Vertical transmission is an important route of transmission for hepatitis B virus infection. Despitethe introduction of HBV vaccine in the extended immunization program in 2005, Cameroonhas remained a hyper-endemic area. The aim of this study was to determine the seroprevalence of hepatitis B Virus among antenatal clinic attenders in Penka-Michel-Cameroon, and to identify potential risk factors associated with the infection for a better prevention of the disease.Original Research Article Study Design:The study was a case control study conducted in four reference hospitals in Penka-Michel, a rural area in west region of Cameroon during April to July 2014. Methodology: Six hundred and forty three(643) pregnant women were recruited. The DiaSpot HBsAgin vitrodiagnostic test strips were first used. Positive samples were further confirmed for HBsAg, HBeAg, anti-HBs, anti-HBe and anti-HBc using an immunoassay kit. Liver enzymes (ALT, AST and ALP) were also evaluatedfor HBsAg positive samplesusing TECO DIAGNOSTICSkit. A structured questionnaire was used to collect information on sociodemographic parameters and predisposing risk factors of hepatitis B from each patient. Data collected was analyzed using Graph Pad prism version 5.03. Results: The prevalence of hepatitis B infection (HBsAg) in our setting was 4.7%. Fifty percent of HBsAg positive women were also HBeAg positive and 46.7% of them lack antibodies against hepatitis B e antigen. All the HBsAg positive women had previous contact with HBV and just 3.3% of them were immunized against HBV. Women in the age groups 31–35 years were significantly more affected (X216.95, P= .0045). Only a history of a contact with hepatitis B infection was significantly associated with HBsAg and HBeAg positivity (X2 27.45, P= .0001; X225.31, P= .0003).Conclusion:Administration of HBIG in combination with hepatitis B vaccine as post-exposure prophylaxis for infants born to HBV infected mothers is of paramount importance. In addition, universal HBsAg screening of all pregnant women will greatly assist in reducing the maternal transmission of HBV in Cameroon.en_US
dc.identifier.affiliationsDepartment of Biochemistry, Faculty of Science, Microbiology and Pharmacology Laboratory, University of Dschang, P.O.Box 67 Dschang, Cameroonen_US
dc.identifier.affiliationsDepartment of Biochemistry, Faculty of Science, Microbiology and Pharmacology Laboratory, University of Dschang, P.O.Box 67 Dschang, Cameroonen_US
dc.identifier.affiliationsDepartment of Microbiology,Faculty of Science,University of Yaoundé I, P.O.Box 812 Yaoundé, Cameroonen_US
dc.identifier.affiliationsDepartment of Microbiology,Faculty of Science,University of Yaoundé I, P.O.Box 812 Yaoundé, Cameroonen_US
dc.identifier.citationLaure Brigitte Kouitcheu Mabeku, Tchakounte Constantin, Flaurant Tchouangueu Thibau, Etoa Francois-Xavier. Associated Risk Factors and Seroprevalence of Hepatitis B among Pregnant Women Attending Antenatal Clinic in a Rural Setting of Cameroon (Penka-Michel). Journal of Advances in Medicine and Medical Research. 2019 Mar; 29(3): 1-12en_US
dc.identifier.issn2456-8899
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210043
dc.languageenen_US
dc.publisherSCIENCEDOMAIN internationalen_US
dc.relation.issuenumber3en_US
dc.relation.volume29en_US
dc.source.urihttps://dx.doi.org//10.9734/JAMMR/2019/v29i330072en_US
dc.subjectHepatitis Ben_US
dc.subjectseroprevalenceen_US
dc.subjectpregnant womenen_US
dc.subjectrural settingen_US
dc.subjectCameroonen_US
dc.titleAssociated Risk Factors and Seroprevalence of Hepatitis B among Pregnant Women Attending Antenatal Clinic in a Rural Setting of Cameroon (Penka-Michel)en_US
dc.typeJournal Articleen_US
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