Hyponatremia in Patients with Cirrhosis of Liver Admitted in the Medicine Ward of SBMCH- Study of 100 Cases

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dc.contributor.authorShahinuzzaman, M Men_US
dc.contributor.authorAhmed, Sen_US
dc.contributor.authorMorshed, Men_US
dc.contributor.authorMasud, Men_US
dc.contributor.authorNajib, A A K.en_US
dc.date.accessioned2025-08-13T10:07:49Z
dc.date.available2025-08-13T10:07:49Z
dc.date.issued2025-06
dc.description.abstractBackground: Hyponatremia is a common and significant complication in cirrhosis, primarily resulting from altered fluid and electrolyte regulation. It is associated with advanced liver disease and poor clinical outcomes. This study aimed to assess the prevalence, clinical characteristics, and prognostic significance of hyponatremia in cirrhotic patients with ascites at Sher-E-Bangla Medical College Hospital (SBMCH), Barisal, Bangladesh. Objective: To evaluate the prevalence of hyponatremia in cirrhotic patients with ascites, its relationship with ascites severity, diuretic therapy, liver dysfunction markers, and its impact on clinical outcomes. Subjects and Methods: This hospital-based, cross-sectional study was conducted over six months (January to June 2012) at SBMCH, including 100 cirrhotic patients with ascites. Data were collected using a structured case record form, documenting demographics, clinical symptoms, biochemical parameters, and sodium levels. Diuretic therapy and ascites characteristics were recorded. Statistical analysis was performed using SPSS, with p-values ?0.05 considered statistically significant. Results: Among the 100 patients studied, 56% had serum sodium concentrations ?130 mmol/L, indicating a high prevalence of hyponatremia. Patients with lower sodium levels had more severe ascites, with 100% of those in the ?130 mmol/L group presenting with refractory ascites. Diuretic therapy, primarily consisting of spironolactone and furosemide, was administered to 84% of the cohort. Serum albumin levels were significantly lower in patients with sodium concentrations ?130 mmol/L. Additionally, the need for paracentesis was more frequent in patients with sodium ?130 mmol/L, reflecting the greater severity of fluid retention in these individuals. Conclusion: Hyponatremia is prevalent in cirrhotic patients, especially those with refractory ascites, and is associated with more severe ascites, hypoalbuminemia, and worsened liver function. Effective management of hyponatremia is critical for improving outcomes in these patients. Further research is needed to explore the mechanisms behind hyponatremia and its impact on liver transplantation outcomes.en_US
dc.identifier.affiliationsAssistant Professor, Department of Medicine, Faridpur Medical College, Faridpur, Bangladeshen_US
dc.identifier.affiliationsProfessor, Department of Obstetrics & Gynaecology, Diabetic Association Medical College, Faridpur, Bangladeshen_US
dc.identifier.affiliationsAssistant Professor, Department of Medicine, Faridpur Medical College, Faridpur, Bangladeshen_US
dc.identifier.affiliationsLecturer, Department of Forensic Medicine, Faridpur Medical college, Faridpur, Bangladeshen_US
dc.identifier.affiliationsRegistrar, Department of Medicine, Faridpur Medical College Hospital, Faridpur, Bangladesh.en_US
dc.identifier.citationShahinuzzaman M M, Ahmed S, Morshed M, Masud M, Najib A A K.. Hyponatremia in Patients with Cirrhosis of Liver Admitted in the Medicine Ward of SBMCH- Study of 100 Cases . Asian Journal of Medical Research. 2025 Jun; 14(2): 10-15en_US
dc.identifier.issn2347-3398
dc.identifier.issn2277-7253
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/253125
dc.languageenen_US
dc.publisherSociety for Healthcare & Research Developmenten_US
dc.relation.issuenumber2en_US
dc.relation.volume14en_US
dc.source.urihttps://aijournals.com/index.php/ajmr/article/view/2632/3382en_US
dc.subjectHyponatremiaen_US
dc.subjectCirrhosisen_US
dc.subjectAscitesen_US
dc.subjectSodium Concentrationen_US
dc.subjectDiuretic Therapyen_US
dc.subjectBangladesh.en_US
dc.titleHyponatremia in Patients with Cirrhosis of Liver Admitted in the Medicine Ward of SBMCH- Study of 100 Casesen_US
dc.typeJournal Articleen_US
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