Host-feeding Preference of Anopheles Species under Prolonged Use of Insecticide-treated Bed Nets in Kamuli District, Uganda: Implications for Vector Control

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dc.contributor.authorKabbale, Fredrick G.en_US
dc.contributor.authorAkol, Anne M.en_US
dc.contributor.authorKaddu, John B.en_US
dc.contributor.authorMatovu, Enocken_US
dc.contributor.authorKazibwe, Anneen_US
dc.contributor.authorYadouleton, Angesen_US
dc.contributor.authorAmbrose, W. Onapaen_US
dc.date.accessioned2020-10-16T08:44:54Z
dc.date.available2020-10-16T08:44:54Z
dc.date.issued2020-03
dc.description.abstractBackground: The blood-feeding patterns are crucial in incriminating disease vectors as well as facilitating the design and consolidation of effective vector control interventions in an area. Objective: This study aimed to establish if prolonged use of insecticide-treated bed nets (ITNs) caused a shift in the preferred hosts of the common malaria vectors as the hosts were under the bed net. Such a shift would render ITNs less effective and would probably explain the continued morbidity and mortality due to malaria in the highly endemic Kamuli district. Methods: A total of 3,519 indoor and outdoor human biting female Anopheles gambiae sensu latoand An. funestusmosquitoes were collected from 48 householdsusing human-baited bed net traps. All 187 indoor resting blood-fed anophelines collected were tested by direct enzyme-linked immunosorbent assay (ELISA) for blood meal host identification. Of these, 73 mid guts came from 24 households in villages with a 69% ITNs coverage, while 114 mid guts were from 24 households in non-ITN villages. Results: Blood meal hosts were identified in only 10.96% (n = 8) and 14.91% (n = 17) of the Anophelesblood meals from the intervention and non-intervention zones, respectively. Other blood meals could not be clearly identified. Eight (100%) blood meals in the intervention zone were from humans, while in the non-intervention zone, 15 (88.24%), one (5.88%) and one (5.88%) came from humans, cattle and goat, respectively. These findings demonstrated that the malaria vectors in Kamuli district are anthropophilic, with nearly all the mosquitoes collected from both zones feeding on humans during every blood meal (p = 0.82). This indicated high vector-human contacts, and thus implicating these species as important in the transmission of Plasmodiumspecies and probably other infections. Conclusion: The use of insecticide-treated bed nets is effective for controlling malaria vectors inside houses, evoking universal coverage of houses in the area.en_US
dc.identifier.affiliationsDepartment of Zoology, Entomology and Fisheries Sciences, College of Natural Sciences, Makerere University, P.O.Box 7062, Kampala, Ugandaen_US
dc.identifier.affiliationsDirectorate of Research and Graduate Studies, Busoga University, P.O.Box 154, Iganga, Ugandaen_US
dc.identifier.affiliationsDepartment of Zoology, Entomology and Fisheries Sciences, College of Natural Sciences, Makerere University, P.O.Box 7062, Kampala, Ugandaen_US
dc.identifier.affiliationsDepartment of Zoology, Entomology and Fisheries Sciences, College of Natural Sciences, Makerere University, P.O.Box 7062, Kampala, Ugandaen_US
dc.identifier.affiliationsDepartment of Molecular Biology, College of Veterinary Medicine, Animal Resources andBiosecurity, Makerere University, P.O.Box 7062, Kampala, Ugandaen_US
dc.identifier.affiliationsCentre de Recherche Entomologique de Cotonou, 06BP Cotoun, 2604, Beninen_US
dc.identifier.affiliationsEnvision/NTD Programme, RTI, Kampala, Ugandaen_US
dc.identifier.citationKabbale Fredrick G., Akol Anne M., Kaddu John B., Matovu Enock, Kazibwe Anne, Yadouleton Anges, Ambrose W. Onapa. Host-feeding Preference of Anopheles Species under Prolonged Use of Insecticide-treated Bed Nets in Kamuli District, Uganda: Implications for Vector Control. International Journal of TROPICAL DISEASE & Health. 2020 Mar; 41(1): 16-25en_US
dc.identifier.issn2278–1005
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/209648
dc.languageenen_US
dc.publisherSCIENCEDOMAIN internationalen_US
dc.relation.issuenumber1en_US
dc.relation.volume41en_US
dc.source.urihttps://dx.doi.org//10.9734/IJTDH/2020/v41i130241en_US
dc.subjectAnopheles mosquitoesen_US
dc.subjecthost preferenceen_US
dc.subjectELISAen_US
dc.subjectITNSen_US
dc.titleHost-feeding Preference of Anopheles Species under Prolonged Use of Insecticide-treated Bed Nets in Kamuli District, Uganda: Implications for Vector Controlen_US
dc.typeJournal Articleen_US
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