Association of BDNF rs6265 and MC4R rs17782313 with metabolic syndrome in Pakistanis

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dc.contributor.authorRana, Sobiaen_US
dc.contributor.authorSultana, Ayeshaen_US
dc.contributor.authorBhatti, Adil Anwaren_US
dc.date.accessioned2020-11-18T10:14:31Z
dc.date.available2020-11-18T10:14:31Z
dc.date.issued2019-09
dc.description.abstractThe goal of the current investigation was to prepare PEGylated Lipova E120 liposomes loaded with celecoxib for theeffective treatment of rheumatoid arthritis (RA). PEGylated liposomes were prepared and were characterized using techniques such as particle size distribution, polydispersity index (PDI), zeta potential, encapsulation efficiency and in-vitrorelease, in-vivo and stability studies. The morphological study was characterized by scanning electron microscopy andtransmission electron microscopy. To determine the interaction between drug and polymer Fourier transform infrared,Raman, thermogravimetric analysis and differential scanning calorimetry studies were performed. Results show that formulation F6 was optimized with a particle size of 92.12 ± 1.7 nm, a PDI of 0.278 ± 0.22, a zeta potential of- 40.8 ± 1.7 mV with a maximum encapsulation of 96.6 ± 0.05% of drug in the PEGylated liposomes. The optimizedformulation shows a maximum release of drug i.e. 94.45 ± 1.13% in 72 h. Tail immersion assay shows that the optimizedformulation F6 significantly increases the reaction time and carrageenan-induced assay shows that the optimized formulation inhibits the increase in paw edema thus providing a pain relief treatment in RA. These results suggest that thePEGylated liposomes provide a sustained release of celecoxib and helps in effective treatment of RA.en_US
dc.identifier.affiliationsMolecular Biology and Human Genetics Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi 75270, Pakistanen_US
dc.identifier.affiliationsMolecular Biology and Human Genetics Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi 75270, Pakistanen_US
dc.identifier.affiliationsMolecular Biology and Human Genetics Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi 75270, Pakistanen_US
dc.identifier.citationRana Sobia, Sultana Ayesha, Bhatti Adil Anwar. Association of BDNF rs6265 and MC4R rs17782313 with metabolic syndrome in Pakistanis. Journal of Biosciences. 2019 Sep; 44(4): 1-11en_US
dc.identifier.issn0250-5991
dc.identifier.issn0973-7138
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/214440
dc.languageenen_US
dc.publisherIndian Academy of Sciencesen_US
dc.relation.issuenumber4en_US
dc.relation.volume44en_US
dc.source.urihttps://dx.doi.org//10.1007/s12038-019-9915-1en_US
dc.subjectAbdominal obesityen_US
dc.subjectBDNF rs6265en_US
dc.subjecthigh-density lipoprotein cholesterolen_US
dc.subjecthyperglycemiaen_US
dc.subjecthypertriglyceridemiaen_US
dc.subjectMC4R rs17782313en_US
dc.titleAssociation of BDNF rs6265 and MC4R rs17782313 with metabolic syndrome in Pakistanisen_US
dc.typeJournal Articleen_US
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