Association of BDNF rs6265 and MC4R rs17782313 with metabolic syndrome in Pakistanis
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Date
2019-09
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Academy of Sciences
Abstract
The goal of the current investigation was to prepare PEGylated Lipova E120 liposomes loaded with celecoxib for theeffective treatment of rheumatoid arthritis (RA). PEGylated liposomes were prepared and were characterized using techniques such as particle size distribution, polydispersity index (PDI), zeta potential, encapsulation efficiency and in-vitrorelease, in-vivo and stability studies. The morphological study was characterized by scanning electron microscopy andtransmission electron microscopy. To determine the interaction between drug and polymer Fourier transform infrared,Raman, thermogravimetric analysis and differential scanning calorimetry studies were performed. Results show that formulation F6 was optimized with a particle size of 92.12 ± 1.7 nm, a PDI of 0.278 ± 0.22, a zeta potential of- 40.8 ± 1.7 mV with a maximum encapsulation of 96.6 ± 0.05% of drug in the PEGylated liposomes. The optimizedformulation shows a maximum release of drug i.e. 94.45 ± 1.13% in 72 h. Tail immersion assay shows that the optimizedformulation F6 significantly increases the reaction time and carrageenan-induced assay shows that the optimized formulation inhibits the increase in paw edema thus providing a pain relief treatment in RA. These results suggest that thePEGylated liposomes provide a sustained release of celecoxib and helps in effective treatment of RA.
Description
Keywords
Abdominal obesity, BDNF rs6265, high-density lipoprotein cholesterol, hyperglycemia, hypertriglyceridemia, MC4R rs17782313
Citation
Rana Sobia, Sultana Ayesha, Bhatti Adil Anwar. Association of BDNF rs6265 and MC4R rs17782313 with metabolic syndrome in Pakistanis. Journal of Biosciences. 2019 Sep; 44(4): 1-11