Involvement of nitric oxide (NO) in the regulation of stress susceptibility and adaptation in rats.

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dc.contributor.authorGulati, Kavitaen_US
dc.contributor.authorRay, Arunabhaen_US
dc.contributor.authorMasood, Anbrinen_US
dc.contributor.authorVijayan, V Ken_US
dc.date.accessioned2009-05-28T13:29:21Z
dc.date.available2009-05-28T13:29:21Z
dc.date.issued2006-10-30en_US
dc.description.abstractThe present study evaluated the regulatory role of nitric oxide (NO) in stress susceptibility and adaptation in rats. Acute restraint stress (RS x1) reduced the number of entries and time spent in the open arms in the elevated plus maze (EPM) test and raised plasma corticosterone levels. RS (x1)-induced neurobehavioral suppression and raised corticosterone levels were attenuated by pretreatment with the NO precursor, L-arginine (500 and 1000 mg/kg)and unaffected or further aggravated by NO synthase inhibitor, L-NAME or 7-nitroindazole (10 and 50 mg/kg). Biochemical assay of plasma and brain homogenates showed that these RS - induced behavioral and neuroendocrinal changes were associated with lowered levels of plasma and brain total nitrates/nitrites (NOx). L-Arginine attenuated the RS-induced suppression of NOx levels in plasma and brain, whereas, the NO synthase inhibitors tended to produce reverse effects. In the experiments involving repeated stress i.e. RS (x5), exposure resulted in attenuation/reversal of (a) neurobehavioral suppression in the EPM test and (b) lowered brain NOx, that was seen after RS (x1). The RS (x5)-induced changes in EPM parameters and brain Nox were further potentiated after L-arginine pretreatment, whereas, the NO synthase inhibitors were less effective. Rats were screened as high and low emotional in the open-field test, and high emotional rats showed greater(a) behavioral suppression in the EPM, (b) corticosterone responses (c) brain NOx suppression, and (d) cold-restraint stress (CRS) induced gastric mucosal lesions as compared to their low emotional counterparts. L-Arginine pretreatment was more effective in modulating the above RS induced stress responses/markers in the high emotional group of rats. Our data suggest that NO plays a differential role during exposure to acute and repeated stress situations, and that the relationship between stress and emotionality status may be under the regulatory influence of NO.en_US
dc.description.affiliationDepartment of Pharmacology and Clinical Research Centre, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 10 007, India.en_US
dc.identifier.citationGulati K, Ray A, Masood A, Vijayan VK. Involvement of nitric oxide (NO) in the regulation of stress susceptibility and adaptation in rats. Indian Journal of Experimental Biology. 2006 Oct; 44(10): 809-15en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59474
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/6619/1/IJEB%2044%2810%29%20809-815.pdfen_US
dc.subject.meshAdaptation, Physiologicalen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArginine --pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNG-Nitroarginine Methyl Ester --pharmacologyen_US
dc.subject.meshNitric Oxide --metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshRestraint, Physicalen_US
dc.subject.meshStress, Physiological --metabolismen_US
dc.titleInvolvement of nitric oxide (NO) in the regulation of stress susceptibility and adaptation in rats.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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