Safety and effectiveness of autoinoculation therapy in cutaneous warts: A double - blind, randomized, placebo - controlled study.

Simple item page
dc.contributor.authorLal, Niharika Ranjan
dc.contributor.authorSil, Amrita
dc.contributor.authorGayen, Tirthankar
dc.contributor.authorBandyopadhyay, Debabrata
dc.contributor.authorDas, Nilay Kanti
dc.date.accessioned2015-01-09T07:16:25Z
dc.date.available2015-01-09T07:16:25Z
dc.date.issued2014-11
dc.description.abstractBackground: In spite of the availability of multiple treatment options, viral warts are known for their persistence and recurrence, causing frustration to patients and treating physicians. Aims: To study the effectiveness and safety of autoinoculation as a treatment modality in cutaneous warts. Methods: A double‑blind, placebo‑controlled study was carried out. In the treatment group, full‑thickness warty tissue was excised, minced and implanted in a small dermal pocket. In the control group, warty tissue was only excised and not implanted, though a dermal pocket was made. Patients were evaluated every four weeks with lesion counts. The procedure was repeated at 4 and 8 weeks. Response was assessed at each visit and at 12 weeks. Results: Forty‑eight patients with cutaneous warts (male: female = 32:16) were randomized into autoinoculation and control groups. The number of warts at baseline was comparable in both groups (P = 0.293). Reduction in the number of warts was significantly more in the autoinoculation group (8.50 ± 13.88) than in the control group (10.04 ± 5.80) from 8 weeks onwards (P = 0.010). Complete resolution occurred only in the autoinoculation group, in 62.5% of cases. Adverse effects were seen in 11 patients, including infection of the donor site (5 cases), keloid formation (3) and hypopigmentation (3). Conclusion: Autoinoculation may be an effective therapeutic modality for cutaneous warts and two sessions may be required for optimum results.en_US
dc.identifier.citationLal Niharika Ranjan, Sil Amrita, Gayen Tirthankar, Bandyopadhyay Debabrata, Das Nilay Kanti. Safety and effectiveness of autoinoculation therapy in cutaneous warts: A double - blind, randomized, placebo - controlled study. Indian Journal of Dermatology, Venereology and Leprology. 2014 Nov-Dec; 80(6): 515-520.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/154886
dc.language.isoenen_US
dc.source.urihttps://www.ijdvl.com/article.asp?issn=0378-6323;year=2014;volume=80;issue=6;spage=515;epage=520;aulast=Lalen_US
dc.subjectAutoinoculationen_US
dc.subjectcutaneous warten_US
dc.subjectplacebo‑controlleden_US
dc.subjectrandomised controlled trialen_US
dc.subject.meshAdult
dc.subject.meshCombined Modality Therapy --methods
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshPlacebos
dc.subject.meshRandomized Controlled Trials as Topic
dc.subject.meshSkin Diseases --therapy
dc.subject.meshVaccination --methods
dc.subject.meshWarts --therapy
dc.titleSafety and effectiveness of autoinoculation therapy in cutaneous warts: A double - blind, randomized, placebo - controlled study.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijdvl2014v80n6p515.pdf
Size:
1.4 MB
Format:
Adobe Portable Document Format
Description:
Original Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Indian Journal of Dermatology, Venereology and Leprology