Safety and effectiveness of autoinoculation therapy in cutaneous warts: A double - blind, randomized, placebo - controlled study.
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Date
2014-11
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Abstract
Background: In spite of the availability of multiple treatment options, viral warts are known
for their persistence and recurrence, causing frustration to patients and treating physicians.
Aims: To study the effectiveness and safety of autoinoculation as a treatment modality in
cutaneous warts. Methods: A double‑blind, placebo‑controlled study was carried out. In the
treatment group, full‑thickness warty tissue was excised, minced and implanted in a small
dermal pocket. In the control group, warty tissue was only excised and not implanted, though
a dermal pocket was made. Patients were evaluated every four weeks with lesion counts.
The procedure was repeated at 4 and 8 weeks. Response was assessed at each visit and at
12 weeks. Results: Forty‑eight patients with cutaneous warts (male: female = 32:16) were
randomized into autoinoculation and control groups. The number of warts at baseline was
comparable in both groups (P = 0.293). Reduction in the number of warts was significantly
more in the autoinoculation group (8.50 ± 13.88) than in the control group (10.04 ± 5.80) from
8 weeks onwards (P = 0.010). Complete resolution occurred only in the autoinoculation group,
in 62.5% of cases. Adverse effects were seen in 11 patients, including infection of the donor
site (5 cases), keloid formation (3) and hypopigmentation (3). Conclusion: Autoinoculation
may be an effective therapeutic modality for cutaneous warts and two sessions may be
required for optimum results.
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Keywords
Autoinoculation, cutaneous wart, placebo‑controlled, randomised controlled trial
Citation
Lal Niharika Ranjan, Sil Amrita, Gayen Tirthankar, Bandyopadhyay Debabrata, Das Nilay Kanti. Safety and effectiveness of autoinoculation therapy in cutaneous warts: A double - blind, randomized, placebo - controlled study. Indian Journal of Dermatology, Venereology and Leprology. 2014 Nov-Dec; 80(6): 515-520.