Involvement of central serotonergic systems in dextromethorphan-induced behavioural syndrome in rats.

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dc.contributor.authorGaikwad, R Ven_US
dc.contributor.authorGaonkar, R Ken_US
dc.contributor.authorJadhav, S Aen_US
dc.contributor.authorThorat, V Men_US
dc.contributor.authorJadhav, J Hen_US
dc.contributor.authorBalsara, J Jen_US
dc.date.accessioned2009-05-28T15:02:15Z
dc.date.available2009-05-28T15:02:15Z
dc.date.issued2005-07-02en_US
dc.description.abstractDextromethorphan, a noncompetitive blocker of the N-methyl-D-aspartate (NMDA) type of glutamate receptor, at 45, 60 and 75 mg/kg, ip doses induced a behavioural syndrome characterised by reciprocal forepaw treading, lateral head-weaving, hind-limb abduction and flat body posture. Such type of behavioural syndrome is induced by 8-hydroxy-2- (di-n-propylamino) tetralin (8-OH-DPAT) by directly stimulating the central postsynaptic 5-hydroxytryptamine (5-HT, serotonin) receptors of the 5-HT1A type. Pretreatment with buspirone (5, 10 mg/kg, ip) and l-propranolol (10, 20 mg/kg, ip) antagonised the behavioural syndrome induced by 8-OH-DPAT and dextromethorphan. Pretreatment with p-chlorophenylalanine (100 mg/kg/day x 4 days) antagonised the behavioural syndrome induced by dextromethorphan and dexfenfluramine but had no significant effect on 8-OH-DPAT induced behavioural syndrome. This indicates that dextromethorphan induces the behavioural syndrome by releasing 5-HT from serotonergic neurons with resultant activation of the postsynaptic 5-HT1A receptors by the released 5-HT. Pretreatment with fluoxetine (10 mg/kg, ip) significantly potentiated the behavioural syndrome induced by dextromethorphan and 5-hydroxytryptophan but significantly antagonised dexfenfluramine induced behavioural syndrome. This indicates that dextromethorphan releases 5-HT by a mechanism which differs from that of dexfenfluramine. Dextromethorphan may be releasing 5-HT by blocking the NMDA receptors and thereby counteracting the inhibitory influence of l-glutamate on 5-HT release.en_US
dc.description.affiliationDepartment of Pharmacology, Krishna Institute of Medical Sciences, Karad 415 110, India.en_US
dc.identifier.citationGaikwad RV, Gaonkar RK, Jadhav SA, Thorat VM, Jadhav JH, Balsara JJ. Involvement of central serotonergic systems in dextromethorphan-induced behavioural syndrome in rats. Indian Journal of Experimental Biology. 2005 Jul; 43(7): 620-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61475
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.mesh8-Hydroxy-2-(di-n-propylamino)tetralin --toxicityen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntitussive Agents --toxicityen_US
dc.subject.meshBehavior, Animal --drug effectsen_US
dc.subject.meshBuspirone --pharmacologyen_US
dc.subject.meshCentral Nervous System --drug effectsen_US
dc.subject.meshDexfenfluramine --toxicityen_US
dc.subject.meshDextromethorphan --toxicityen_US
dc.subject.meshFluoxetine --pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPropranolol --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSerotonin --physiologyen_US
dc.subject.meshSerotonin Agonists --toxicityen_US
dc.subject.meshSyndromeen_US
dc.titleInvolvement of central serotonergic systems in dextromethorphan-induced behavioural syndrome in rats.en_US
dc.typeJournal Articleen_US
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