Organochlorine pesticide-induced oxidative stress and immune suppression in rats.

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dc.contributor.authorKoner, B Cen_US
dc.contributor.authorBanerjee, B Den_US
dc.contributor.authorRay, Aen_US
dc.date.accessioned2009-05-28T13:05:53Z
dc.date.available2009-05-28T13:05:53Z
dc.date.issued1998-04-26en_US
dc.description.abstractEffects of subchronic DDT and lindane exposure were evaluated on lipid peroxidation, antioxidant mechanisms and humoral immune response in rats. Oral administration of DDT, (100 and 200 ppm) and lindane (40 and 80 ppm) dose dependently increased thiobarbituric acid reactive substance (TBARS) levels in serum after 8 wk of treatment. Superoxide dismutase (SOD) activity in red blood cells (RBC) was also dose dependently increased by these compounds. In addition, such DDT or lindane exposure markedly suppressed the humoral immune response as assessed by anti-sheep RBC antibody titres. Simultaneous treatment with ascorbic acid (100 mg/kg) markedly attenuated the effects of DDT and lindane on (a) lipid peroxidation, (b) SOD activity and (c) humoral immune suppression. These results indicate the possible involvement of free radicals in organochlorine-induced immunotoxicity.en_US
dc.description.affiliationDepartment of Biochemistry and Pharmacology, University College of Medical Sciences and G.T.B. Hospital, University of Delhi, India.en_US
dc.identifier.citationKoner BC, Banerjee BD, Ray A. Organochlorine pesticide-induced oxidative stress and immune suppression in rats. Indian Journal of Experimental Biology. 1998 Apr; 36(4): 395-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58959
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibody Formation --drug effectsen_US
dc.subject.meshDDT --toxicityen_US
dc.subject.meshInsecticides --toxicityen_US
dc.subject.meshLindane --toxicityen_US
dc.subject.meshMaleen_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.titleOrganochlorine pesticide-induced oxidative stress and immune suppression in rats.en_US
dc.typeJournal Articleen_US
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