Gastroprotective Effect of Tabernaemontana divaricata (Linn.) R.Br. Flower Methanolic Extract in Wistar Rats.
Loading...
Date
2011-07
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Tabernaemontana divaricata (L.) R.Br belonging to Apocynaceae family is traditionally
used by people in many parts of the world to treat various disorders. The present study
was undertaken to investigate anti-ulcer property of Tabernaemontana divaricata flower
methanolic extract (TDFME 500 mg/kg, p.o) by pyloric ligation induced gastric ulceration
model using Omeprazole (8mg/kg, p.o) as a standard drug in wistar rats. Five
parameters i.e., volume of gastric juice, pH, free & total acidities and ulcer index were
assessed. The test extract significantly (p< 0.01) decreased volume of gastric juice, free
& total acidities and ulcer index. Like standard, it also raised pH of gastric acid. The
observed percentage protection for standard and test were 89.84% and 79.53%,
respectively. Thus, TDFME 500 mg/kg had a positive effect on all the parameters under
study and the results were similar to that of standard. From the above results, it can be
concluded that TDFME exhibits remarkable gastroprotective effect.
Description
Keywords
Peptic Ulcer Disease (PUD), Tabernaemontana divaricata, flower, methanolic extract, pyloric ligation, gastric ulceration model, ulcer index
Citation
Khan Mohammed Safwan Ali. Gastroprotective Effect of Tabernaemontana divaricata (Linn.) R.Br. Flower Methanolic Extract in Wistar Rats. British Journal of Pharmaceutical Research. 2011 Jul-Sep; 1(3): 88-98.