Cell adhesion by aqueous extract of human placenta used as wound healer.

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dc.contributor.authorNath, Sangeetaen_US
dc.contributor.authorBhattacharyya, Debasishen_US
dc.date.accessioned2009-05-28T13:06:30Z
dc.date.available2009-05-28T13:06:30Z
dc.date.issued2007-08-20en_US
dc.description.abstractAqueous extract of human placenta, used as wound healer, has shown significant cell adhesion property on mouse peritoneal macrophages and P388D1 cultured macrophage cell line. This property was offered primarily by fibronectin type III like peptide present in the extract and is comparable to fibronectin on a molar basis. The peptide induce adhesion of cell through cell surface receptors having K(d) = 2.8 +/- 0.9 x 10(-5) M suggesting weak binding. This is in support of integrins receptors that typically exhibit low affinities. Cell adhesion was partially inhibited by Arg-Gly-Asp (RGD) peptide, anti-beta1 integrin suggesting that integrin beta1 receptors have roles to play in the process.en_US
dc.description.affiliationDivision of Structural Biology and Bioinformatics, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Jadavpur, Kolkata 700 032, India.en_US
dc.identifier.citationNath S, Bhattacharyya D. Cell adhesion by aqueous extract of human placenta used as wound healer. Indian Journal of Experimental Biology. 2007 Aug; 45(8): 732-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58973
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/5312/1/IJEB%2045%288%29%20732-738.pdfen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntigens, CD29 --drug effectsen_US
dc.subject.meshCell Adhesion --drug effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFibronectins --pharmacologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMacrophages, Peritoneal --drug effectsen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred BALB Cen_US
dc.subject.meshOligopeptides --pharmacologyen_US
dc.subject.meshPlacental Extracts --pharmacologyen_US
dc.subject.meshWater --chemistryen_US
dc.subject.meshWound Healing --drug effectsen_US
dc.titleCell adhesion by aqueous extract of human placenta used as wound healer.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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