Safety of 0.1% topical tacrolimus in the treatment of vitiligo.

Simple item page
dc.contributor.authorHazra, S C
dc.contributor.authorAhmed, N
dc.contributor.authorGhosh, J C
dc.date.accessioned2015-12-09T09:11:23Z
dc.date.available2015-12-09T09:11:23Z
dc.date.issued2014-07
dc.description.abstractCure rates for vitiligo are significantly lower because of problems to different studies have reported different response rate and different adverse effect for the treatment of vitiligo. This study was conducted to evaluate the response rate and adverse effect of topical tacrolimus 0.1% ointment in the treatment of vitiligo patients in the department of Dermatology and venereology, Bangladesh Medical college (BMC), Dhaka from January 2010 to July 2010. In this clinical trial, 30 newly diagnosed vitiligo (focal and segmental) patients, aged between 10 to 50 years were assigned for therapy and to observe the response and adverse effect. Each individual lesion was treated with topical tacrolimus 0.1% ointment twice daily for three months. All the patients completed three months treatment and available for statistical analysis. The highest percentage 13(43.3%) was in the age of 11-20 years. Sex ratio revealed higher in case of female 18(60%), with a male-female ratio 1:1.5 and 5(16.67%) patients had vitiligo among their families. Repigmentation was observed in 8 (26.7%) subjects at the end of 4th week, 15 (50.1%) subjects at 8th week and 25 (83.3%) subjects after 12 weeks of therapy. 25 (83.33%) subjects did not complain any adverse effect (like pruritus, burning etc.) and 5 (16.67%) subjects were suffered from different adverse effect of drug, like pruritus observed in 2 (6.7%) subjects and burning in 6 (20%) subjects. This study found that tacrolimus 0.1% ointment to be safe in the treatment of vitiligo, with reduction in the number of vitiliginous spots by increased repigmentation significantly.en_US
dc.identifier.citationHazra SC, Ahmed N, Ghosh J C. Safety of 0.1% topical tacrolimus in the treatment of vitiligo. Bangladesh Journal of Medical Science. 2014; 13(3): 255-259.en_US
dc.identifier.issn2223-4721
dc.identifier.issn2076-0299
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/167640
dc.language.isoenen_US
dc.source.urihttps://www.banglajol.info/bd/index.php/BJMS/article/view/19147en_US
dc.subjectsafety of tacrolimusen_US
dc.subjecttreatment of vitiligoen_US
dc.titleSafety of 0.1% topical tacrolimus in the treatment of vitiligo.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
bjms2014v13n3p255.pdf
Size:
275.42 KB
Format:
Adobe Portable Document Format
Description:
Original article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Bangladesh Journal of Medical Science