Dietary cardamom inhibits the formation of azoxymethane-induced aberrant crypt foci in mice and reduces COX-2 and iNOS expression in the colon.

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dc.contributor.authorSengupta, Archanaen_US
dc.contributor.authorGhosh, Samiten_US
dc.contributor.authorBhattacharjee, Shameeen_US
dc.date.accessioned2009-05-27T17:33:30Z
dc.date.available2009-05-27T17:33:30Z
dc.date.issued2005-04-17en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractRecently, considerable attention has been focused on identifying naturally occurring chemopreventive compounds capable of inhibiting, retarding, or reversing the multi-step carcinogenesis. The primary aim of the present study was to identify the effects of a commonly consumed spice, viz., cardamom against azoxymethane (AOM) induced colonic aberrant crypt foci (ACF) in Swiss Albino mice. The secondary aim, was to explore the ability of cardamom to modulate the status of proliferation and apoptosis, and to understand its role in altering cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression. Male Swiss albino mice were injected with AOM (dose: 5mg/Kg body weight) or saline (Group 1) weekly once for two weeks. The AOM-injected mice were randomly assigned to two groups (Groups 2 and 3). While all the groups were on standard lab chow, Group 3 received oral doses of 0.5% cardamom, in aqueous suspension, daily for 8 weeks. Following treatment, significant reduction in the incidences of aberrant crypt foci (p<0.05) was observed. This reduction in ACF was accompanied by suppression of cell proliferation (mean Brdu LI in carcinogen control =13.91+/-3.31, and 0.5% cardamom =2.723+/-0.830) and induction of apoptosis (mean AI in carcinogen control=1.547+/-0.42 and 0.5% cardamom = 6.61+/-0.55). Moreover, reduction of both COX-2 and iNOS expression was also observed. These results suggest that aqueous suspensions of cardamom have protective effects on experimentally induced colon carcinogenesis. Cardamom as a whole and its active components require further attention if the use of this spice is to be recommended for cancer prevention.en_US
dc.description.affiliationDepartment of Cancer Chemoprevention, Chittaranjan National Cancer Institute, Kolkata 700026, India. archana_sen@yahoo.comen_US
dc.identifier.citationSengupta A, Ghosh S, Bhattacharjee S. Dietary cardamom inhibits the formation of azoxymethane-induced aberrant crypt foci in mice and reduces COX-2 and iNOS expression in the colon. Asian Pacific Journal of Cancer Prevention. 2005 Apr-Jun; 6(2): 118-22en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37400
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnticarcinogenic Agents --pharmacologyen_US
dc.subject.meshApoptosis --drug effectsen_US
dc.subject.meshAzoxymethane --toxicityen_US
dc.subject.meshBlotting, Westernen_US
dc.subject.meshCarcinogens --toxicityen_US
dc.subject.meshColonic Diseases --chemically induceden_US
dc.subject.meshColonic Neoplasms --chemically induceden_US
dc.subject.meshCyclooxygenase 2en_US
dc.subject.meshElettariaen_US
dc.subject.meshMiceen_US
dc.subject.meshNitric Oxide Synthase --metabolismen_US
dc.subject.meshNitric Oxide Synthase Type IIen_US
dc.subject.meshPrecancerous Conditions --chemically induceden_US
dc.subject.meshProstaglandin-Endoperoxide Synthases --metabolismen_US
dc.subject.meshRandom Allocationen_US
dc.titleDietary cardamom inhibits the formation of azoxymethane-induced aberrant crypt foci in mice and reduces COX-2 and iNOS expression in the colon.en_US
dc.typeJournal Articleen_US
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