Extremely low frequency magnetic exposure attenuates oxidative stress and apoptotic cell death in injured spinal cord of rats

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dc.contributor.authorAMBALAYAM, SAJEEVen_US
dc.contributor.authorMathur, Rashmien_US
dc.date.accessioned2023-08-09T06:20:17Z
dc.date.available2023-08-09T06:20:17Z
dc.date.issued2022-04
dc.description.abstractSecondary spinal cord injury (SCI) sets on immediately after trauma which results in vascular, morphological and biochemical changes at the site of lesion. Amongst these, the crucial events such as oxidative stress and apoptosis result in spreading the injury to adjacent tissues following the initial insult. Exposure to extremely low frequency magnetic field (ELFMF) is reported to modulate oxidative stress and cell death in vivo. Here, we investigated the influence of ELFMF on oxidative stress and cell death after SCI. Adult male Wistar rats were divided into Sham-SCI (Laminectomy only), Sham-SCI+MF (ELFMF exposure; 17.96 ?T intensity, 50 Hz frequency, 2 h duration/day to Sham-SCI rats), SCI (complete transection of T13 spinal cord) and SCI+MF (ELFMF exposure to SCI rats) groups. They were sacrificed on day 2 for antioxidant assay and day 1, 2 and 3 for cell death study. The oxidative stress was assessed by antioxidant enzyme activities and the cell death was assessed by TUNEL assay and Caspase-3 immnuohistochemistry. Data revealed significant reduction in the lipid peroxidation and number of cells undergone cell death besides improvement in antioxidant levels in the spinal cord of ELFMF exposed SCI rats. These novel findings demonstrate the potential of ELFMF to attenuate oxidative stress and cell death in the early stage of secondary injury process after SCI.en_US
dc.identifier.affiliationsDepartment of Physiology, University College of Medical Sciences, Dilshad garden, Delhi-110095, Indiaen_US
dc.identifier.affiliationsDepartment of Physiology, NDMC Medical College and Hindurao Hospital, New Delhi-110007, Indiaen_US
dc.identifier.citationAMBALAYAM SAJEEV, Mathur Rashmi. Extremely low frequency magnetic exposure attenuates oxidative stress and apoptotic cell death in injured spinal cord of rats. Indian Journal of Experimental Biology. 2022 Apr; 60(4): 248-257en_US
dc.identifier.issn0975-1009
dc.identifier.issn0019-5189
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/222480
dc.languageenen_US
dc.publisherCSIR-NIScPRen_US
dc.relation.issuenumber4en_US
dc.relation.volume60en_US
dc.source.urihttps://doi.org/10.56042/ijeb.v60i04.53721en_US
dc.subjectApoptosisen_US
dc.subjectSpinal cord injury (SCI)en_US
dc.subjectTUNELen_US
dc.titleExtremely low frequency magnetic exposure attenuates oxidative stress and apoptotic cell death in injured spinal cord of ratsen_US
dc.typeJournal Articleen_US
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