Relationship between systemic hypertension, perfusion pressure and glaucoma: A comparative study in an adult Indian population.

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dc.contributor.authorDeb, Amit K
dc.contributor.authorKaliaperumal, Subashini
dc.contributor.authorRao, Vasudev A
dc.contributor.authorSengupta, Sabyasachi
dc.date.accessioned2015-02-03T09:51:19Z
dc.date.available2015-02-03T09:51:19Z
dc.date.issued2014-09
dc.description.abstractAims: To study the relationship between blood pressure (BP), intraocular pressure (IOP), mean ocular perfusion pressure (MOPP) and primary open angle glaucoma (POAG) in patients with hypertension and compare it to a control group of normotensives. Design: Cross‑sectional observational study. Materials and Methods: A total of 108 subjects with primary hypertension and 100 age‑matched controls without hypertension were enrolled for the study. IOP measurement using Noncontact Tonometer and dilated fundus evaluation using + 90 D lens were done for all cases. Single recording of BP was taken. Gonioscopy, Humphrey’s central visual fields, optical coherence tomography and pachymetry were done for all subjects with IOP > 21 mm Hg or C: D ratio ≥ 0.5 or asymmetry of > 0.2. Statistical Analysis: Univariate and multivariate multinomial regression models were used to determine the association between covariates and risk of glaucoma or glaucoma suspect. Results: There was no difference in the glaucoma status between subjects with and without hypertension. Subjects on antihypertensive medications were 1½ times more likely to have suspicious glaucoma (odds ratio [OR] =1.56] and nearly twice as likely to have POAG (OR = 1.85). In addition, we found a 31% and 12% reduction in risk of having POAG (95% confidence interval [CI] =13–45%, P = 0.001) and glaucoma suspect (95% CI = 2–21%, P = 0.03) respectively with every 1 mm Hg increment in MOPP. Conclusion: Subjects on antihypertensive medications are more likely to have either glaucoma or glaucoma suspect, and higher ocular perfusion pressure offers relative protection from glaucomatous damage.en_US
dc.identifier.citationDeb Amit K, Kaliaperumal Subashini,Rao Vasudev A, Sengupta Sabyasachi. Relationship between systemic hypertension, perfusion pressure and glaucoma: A comparative study in an adult Indian population. Indian Journal of Ophthalmology. 2014 Sept ; 62 (9): 917-922.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/155747
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244736/en_US
dc.subjectocular perfusion pressureen_US
dc.subjectopen‑angle glaucomaen_US
dc.subjectsystemic hypertensionen_US
dc.titleRelationship between systemic hypertension, perfusion pressure and glaucoma: A comparative study in an adult Indian population.en_US
dc.typeArticleen_US
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