Relationship between systemic hypertension, perfusion pressure and glaucoma: A comparative study in an adult Indian population.
dc.contributor.author | Deb, Amit K | |
dc.contributor.author | Kaliaperumal, Subashini | |
dc.contributor.author | Rao, Vasudev A | |
dc.contributor.author | Sengupta, Sabyasachi | |
dc.date.accessioned | 2015-02-03T09:51:19Z | |
dc.date.available | 2015-02-03T09:51:19Z | |
dc.date.issued | 2014-09 | |
dc.description.abstract | Aims: To study the relationship between blood pressure (BP), intraocular pressure (IOP), mean ocular perfusion pressure (MOPP) and primary open angle glaucoma (POAG) in patients with hypertension and compare it to a control group of normotensives. Design: Cross‑sectional observational study. Materials and Methods: A total of 108 subjects with primary hypertension and 100 age‑matched controls without hypertension were enrolled for the study. IOP measurement using Noncontact Tonometer and dilated fundus evaluation using + 90 D lens were done for all cases. Single recording of BP was taken. Gonioscopy, Humphrey’s central visual fields, optical coherence tomography and pachymetry were done for all subjects with IOP > 21 mm Hg or C: D ratio ≥ 0.5 or asymmetry of > 0.2. Statistical Analysis: Univariate and multivariate multinomial regression models were used to determine the association between covariates and risk of glaucoma or glaucoma suspect. Results: There was no difference in the glaucoma status between subjects with and without hypertension. Subjects on antihypertensive medications were 1½ times more likely to have suspicious glaucoma (odds ratio [OR] =1.56] and nearly twice as likely to have POAG (OR = 1.85). In addition, we found a 31% and 12% reduction in risk of having POAG (95% confidence interval [CI] =13–45%, P = 0.001) and glaucoma suspect (95% CI = 2–21%, P = 0.03) respectively with every 1 mm Hg increment in MOPP. Conclusion: Subjects on antihypertensive medications are more likely to have either glaucoma or glaucoma suspect, and higher ocular perfusion pressure offers relative protection from glaucomatous damage. | en_US |
dc.identifier.citation | Deb Amit K, Kaliaperumal Subashini,Rao Vasudev A, Sengupta Sabyasachi. Relationship between systemic hypertension, perfusion pressure and glaucoma: A comparative study in an adult Indian population. Indian Journal of Ophthalmology. 2014 Sept ; 62 (9): 917-922. | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/155747 | |
dc.language.iso | en | en_US |
dc.source.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244736/ | en_US |
dc.subject | ocular perfusion pressure | en_US |
dc.subject | open‑angle glaucoma | en_US |
dc.subject | systemic hypertension | en_US |
dc.title | Relationship between systemic hypertension, perfusion pressure and glaucoma: A comparative study in an adult Indian population. | en_US |
dc.type | Article | en_US |
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