Relationship between systemic hypertension, perfusion pressure and glaucoma: A comparative study in an adult Indian population.
Loading...
Date
2014-09
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Aims: To study the relationship between blood pressure (BP), intraocular pressure (IOP), mean ocular
perfusion pressure (MOPP) and primary open angle glaucoma (POAG) in patients with hypertension and
compare it to a control group of normotensives. Design: Cross‑sectional observational study. Materials
and Methods: A total of 108 subjects with primary hypertension and 100 age‑matched controls without
hypertension were enrolled for the study. IOP measurement using Noncontact Tonometer and dilated
fundus evaluation using + 90 D lens were done for all cases. Single recording of BP was taken. Gonioscopy,
Humphrey’s central visual fields, optical coherence tomography and pachymetry were done for all subjects
with IOP > 21 mm Hg or C: D ratio ≥ 0.5 or asymmetry of > 0.2. Statistical Analysis: Univariate and
multivariate multinomial regression models were used to determine the association between covariates and
risk of glaucoma or glaucoma suspect. Results: There was no difference in the glaucoma status between
subjects with and without hypertension. Subjects on antihypertensive medications were 1½ times more likely
to have suspicious glaucoma (odds ratio [OR] =1.56] and nearly twice as likely to have POAG (OR = 1.85). In
addition, we found a 31% and 12% reduction in risk of having POAG (95% confidence interval [CI] =13–45%,
P = 0.001) and glaucoma suspect (95% CI = 2–21%, P = 0.03) respectively with every 1 mm Hg increment in
MOPP. Conclusion: Subjects on antihypertensive medications are more likely to have either glaucoma or
glaucoma suspect, and higher ocular perfusion pressure offers relative protection from glaucomatous damage.
Description
Keywords
ocular perfusion pressure, open‑angle glaucoma, systemic hypertension
Citation
Deb Amit K, Kaliaperumal Subashini,Rao Vasudev A, Sengupta Sabyasachi. Relationship between systemic hypertension, perfusion pressure and glaucoma: A comparative study in an adult Indian population. Indian Journal of Ophthalmology. 2014 Sept ; 62 (9): 917-922.